VT104

An inhibitor of TEAD autopalmitoylation, inhibits autopalmitoylation of TEAD1-4 in HEK293 cells expressing the human transcription factors at 3 µM, inhibits the growth of NCI-H2052, NCI-H2373, and NCI H226 cells (IC50s = 31.6, 25.6, and 16.1 nM, respectively), reduces tumor volume in an NCI H226 mouse xenograft model at 1, 3, and 10 mg/kg. SMILES: C[C@@H](C1=CC=CC=N1)NC(C2=CC(C=CC=C3C4=CC=C(C(F)(F)F)C=C4)=C3C=C2)=O. InChi Code: InChI=1S/C25H19F3N2O/c1-16(23-7-2-3-14-29-23)30-24(31)19-10-13-22-18(15-19)5-4-6-21(22)17-8-11-20(12-9-17)25(26,27)28/h2-16H,1H3,(H,30,31)/t16-/m0/s1. InChi Key: AAZUPSFRSHFTGV-INIZCTEOSA-N