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NEU
VT104
Artikelnummer: Cay45223-10
An inhibitor of TEAD autopalmitoylation, inhibits autopalmitoylation of TEAD1-4 in HEK293 cells expressing the human transcription factors at 3 µM, inhibits the growth of NCI-H2052, NCI-H2373, and NCI H226 cells (IC50s = 31.6, 25.6, and 16.1 nM, respectively), reduces tumor volume in an NCI H226 mouse xenograft...
| Schlagworte: | N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide |
| Anwendung: | TEAD autopalmitoylation inhibitor |
| CAS | 2417718-25-1 |
| MW: | 420.44 D |
ab 115,00 €
VT104
Artikelnummer: TGM-T67872-10mg
Description: VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins. Target: YAP. Smiles: C[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1ccccn1. References: Barry ER, et al. Recent Therapeutic Approaches to...
| CAS | 2417718-25-1 |
| MW: | 420.43 D |
ab 68,00 €
