Zu "K09448" wurden 139 Artikel gefunden!
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NEU
YAP/TAZ Inhibitor-3
Artikelnummer: Cay45146-1
An inhibitor of the TEAD-YAP/TAZ protein-protein interaction, inhibits TEAD1-4 palmitoylation in HEK293T cells expressing TEAD1-4 at 3 µM, inhibits the proliferation of a variety of mesothelioma cells, including those with homozygous expression of NF2 mutations (GI50s = 8-74 nM) or heterozygous expression of NF2...
| Schlagworte: | VT3989, N-[(1R)-2-hydroxy-1-methylethyl]-5-[4-(trifluoromethyl)phenoxy]-2-naphthalenecarboxamide |
| Anwendung: | TEAD-YAP/TAZ protein-protein interaction inhibitor |
| CAS | 2506273-81-8 |
| MW: | 389.37 D |
ab 203,00 €
NEU
VT104
Artikelnummer: Cay45223-10
An inhibitor of TEAD autopalmitoylation, inhibits autopalmitoylation of TEAD1-4 in HEK293 cells expressing the human transcription factors at 3 µM, inhibits the growth of NCI-H2052, NCI-H2373, and NCI H226 cells (IC50s = 31.6, 25.6, and 16.1 nM, respectively), reduces tumor volume in an NCI H226 mouse xenograft...
| Schlagworte: | N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxamide |
| Anwendung: | TEAD autopalmitoylation inhibitor |
| CAS | 2417718-25-1 |
| MW: | 420.44 D |
ab 115,00 €
Anti-TEAD1
Artikelnummer: ATA-HPA046053.100
Rabbit Polyclonal TEAD1 Antibody against Human TEA domain transcription factor 1. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000055320: 97%,...
| Schlagworte: | Anti-TCF13, Anti-TEAD1, Anti-TEAD-1, Anti-TCF-13, Anti-NTEF-1, Anti-Protein GT-IIC, Anti-Transcription factor 13, Anti-TEA... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 369,00 €
Anti-TEAD4
Artikelnummer: ATA-HPA060877.100
Rabbit Polyclonal TEAD4 Antibody against Human TEA domain transcription factor 4. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000030353: 80%,...
| Schlagworte: | Anti-RTEF1, Anti-TEAD4, Anti-TEAD-4, Anti-TEA domain family member 4, Anti-Transcription factor RTEF-1, Anti-Transcription... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
491,00 €
VT103
Artikelnummer: Cay42327-1
A TEAD1 inhibitor (IC50 = 1.02 nM), inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2, TEAD3, or TEAD4 at 3 µM, inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 cells, reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models....
| Schlagworte: | N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-benzenesulfonamide |
| Anwendung: | TEAD1 inhibitor |
| CAS | 2290608-13-6 |
| MW: | 410.41 D |
ab 112,00 €
TEAD1 Cofactor-Binding Domain (human, recombinant)
Artikelnummer: Cay35888-100
Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...
| Schlagworte: | TCF13, TEAD1, NTEF-1, TEAD-1, TCF-13, Protein GT-IIC, Transcription factor 13, TEA domain family member 1, Transcriptional... |
| Anwendung: | Active protein |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
814,00 €
Hippo Pathway TEAD Reporter - MCF7 Cell Line
Artikelnummer: BPS-60618
The TEAD Reporter - MCF7 cell line contains the firefly luciferase gene under the control of TEAD responsive elements stably integrated into the human breast cancer cell line, MCF7. Inside the cells, basal unphosphorylated YAP/TAZ remains in the nucleus and induces the constitutive expression of luciferase reporter....
| Schlagworte: | Hippo, Hippo signalling pathway, Hippo signalling cascade, Salvador-Warts-Hippo signalling pathway, SWH signalling pathway, |
| Anwendung: | Monitor Hippo pathway activity, activator / inhibitor screening |
| Spezies-Reaktivität: | human |
3.980,00 €
Anti-TEAD4
Artikelnummer: ATA-HPA056896.100
Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...
| Schlagworte: | Anti-TEAD4, Anti-RTEF1, Anti-TEAD-4, Anti-TEA domain family member 4, Anti-Transcription factor RTEF-1, Anti-Transcription... |
| Anwendung: | ChIP, ICC, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-TEAD1
Artikelnummer: ARG55099.100
Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...
| Schlagworte: | Anti-TCF13, Anti-TEAD1, Anti-NTEF-1, Anti-TCF-13, Anti-TEAD-1, Anti-Protein GT-IIC, Anti-Transcription factor 13, Anti-TEA... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
Anti-TEAD3
Artikelnummer: ARG55100.100
Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...
| Schlagworte: | Anti-TEAD3, Anti-TEAD5, Anti-TEAD-3, Anti-DTEF-1, Anti-TEA domain family member 3, Anti-Transcriptional enhancer factor TEF-5 |
| Anwendung: | WB, IHC, ICC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
707,00 €
Anti-TEF4, Internal
Artikelnummer: ARG64894.100
Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...
| Schlagworte: | Anti-TEF4, Anti-TEAD2, Anti-TEAD-2, Anti-TEA domain family member 2, Anti-Transcriptional enhancer factor TEF-4 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
Anti-TEAD2
Artikelnummer: NSJ-R33920-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: TEA domain family member 2 Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by...
| Schlagworte: | Anti-TEF4, Anti-TEAD2, Anti-TEAD-2, Anti-TEA domain family member 2, Anti-Transcriptional enhancer factor TEF-4, TEAD2... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €