USP7-USP47 Inhibitor

USP7-USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 (IC50s = 0.42 and 1 µM, respectively). It is selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC50s = >31.6 µM). USP7-USP47 inhibitor inhibits the growth of HCT116 cells (EC50 = 7.6 µM).Formal Name: 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-2-thiophenecarboxamide. CAS Number: 1247825-37-1. Molecular Formula: C18H11Cl2N3O3S3. Formula Weight: 484.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 44 mg/ml. lambdamax: 237, 326 nm. SMILES: CS(C1=CC=C(NC(C2=CC(C#N)=C(SC3=C(Cl)C=NC=C3Cl)S2)=O)C=C1)(=O)=O. InChi Code: InChI=1S/C18H11Cl2N3O3S3/c1-29(25,26)12-4-2-11(3-5-12)23-17(24)15-6-10(7-21)18(27-15)28-16-13(19)8-22-9-14(16)20/h2-6,8-9H,1H3,(H,23,24). InChi Key: GUDJFFQZIISQJB-UHFFFAOYSA-N.