UK-122 TFA salt

Description: UK-122 is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) > 100 micromol/L) but significantly inhibited the migration and invasion of this pancreatic cancer cell line. Target: Others. Smiles: C(C(O)=O)(F)(F)F.C(=C\1/N=C(OC1=O)C2=CC=CC=C2)\C3=CC=C(C(=N)N)C=C3. References: Banyard J, Chung I, Migliozzi M, Phan DT, Wilson AM, Zetter BR, Bielenberg DR. Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer. BMC Cancer. 2014 May 30,14:387. doi: 10.1186/1471-2407-14-387. PubMed PMID: 24885350, PubMed Central PMCID: PMC4046438.