UCB 9608

UCB 9608 is an inhibitor of PI4KIIIbeta (IC50 = 11 nM). It is selective for PI4KIIIbeta over 8 other phosphatidylinositol kinases at 10 µM. UCB 9608 inhibits the mixed lymphocyte reaction in isolated human peripheral blood mononuclear cells (PBMCs, IC50 = 37 nM). It increases heart allograft survival in mice when administered at a dose of 5 mg/kg per day.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: .