THPN

THPN is an inducer of autophagy and a derivative of gallic acid (Cay-11846). It binds to the ligand-binding domain (LBD) of Nur77 (Kd = 0.27 µM), which increases NIP3L-facilitated translocation of Nur77 to the mitochondria and induces autophagy in A375 melanoma cells. THPN reduces viability of L1210 and CEM leukemia cells (IC50s = 22 and 50 µM, respectively). It also reduces cytoplasmic and mitochondrial glutathione levels and increases NF-kappaB levels in L1210 cells. THPN (20 mg/kg) inhibits the formation of tumors in the lungs and liver in a B16/F10 murine melanoma model.. SMILES: CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O. InChi Code: InChI=1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3. InChi Key: NVFRHTFJDGAFQS-UHFFFAOYSA-N