TEPP-46

Description: TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. . Target: PKM. Smiles: Cn1c2cc(sc2c2cnn(Cc3cccc(N)c3)c(=O)c12)S(C)=O. References: Walsh M J , Brimacombe K R , Anastasiou D , et al. ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed, 2009.