TCS 5861528

The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse, potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. TCS 5861528 is a selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (Cay-32100) with IC50 values of 14.3 and 18.7 µM, respectively. At 30 mg/kg twice daily in rats, TCS 5861528 has been used to attenuate pain-related behavior in models of diabetic hypersensitivity and postoperative pain.Formal Name: 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide. CAS Number: 332117-28-9. Molecular Formula: C19H23N5O3. Formula Weight: 369.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 15 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 248 nm. SMILES: CN(C(N1C)=O)C2=C(N(CC(NC3=CC=C(C(CC)C)C=C3)=O)C=N2)C1=O. InChi Code: InChI=1S/C19H23N5O3/c1-5-12(2)13-6-8-14(9-7-13)21-15(25)10-24-11-20-17-16(24)18(26)23(4)19(27)22(17)3/h6-9,11-12H,5,10H2,1-4H3,(H,21,25). InChi Key: ZUTUWJYMCADJHD-UHFFFAOYSA-N.