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Zu "K04984" wurden 31 Artikel gefunden!
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Artikelnummer: Cay37495-10
Wasabi receptor toxin (WaTx) (36-68) is a cell-penetrating peptide that corresponds to the mature toxin sequence and is an activator of transient receptor potential ankyrin 1 (TRPA1). It selectively induces currents in HEK293T cells expressing human TRPA1 (EC50 = 15 nM) over cells expressing human TRP melastatin 8...
Schlagworte: | Wasabi Receptor Toxin (36-68),... |
Anwendung: | Cell-penetrating peptide, TRPA1 activator |
MW: | 3855.3 D |
ab 93,00 €
Artikelnummer: ELK-ELK4687.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TRPA1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TRPA1. Next,...
Schlagworte: | p120, Wasabi receptor, Transformation-sensitive protein p120, Ankyrin-like with transmembrane domains protein 1, Transient... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay11923-50
Transient receptor potential cation channel A1 (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds. HC-030031 is a selective TRPA1 blocker, antagonizing...
Schlagworte: | 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide |
Anwendung: | TRPA1 blocker |
CAS | 349085-38-7 |
MW: | 355.4 D |
ab 35,00 €
Artikelnummer: Cay15207-10
The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. A-967079 is a potent, selective, and bioavailable inhibitor of the...
Schlagworte: | (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime |
Anwendung: | TRPA1 inhibitor |
CAS | 1170613-55-4 |
MW: | 207.3 D |
ab 88,00 €
Artikelnummer: LKT-A4441.1
An aqueous solution (with 0.1 % formic acid as a stabilizer) of allicin at 25 mg/mL. The main biologically active compound in garlic. It exerts various biological effects, including antiproliferative, chemopreventive, antioxidant, antihyperlipidaemic and antihypertensive effects. It has been shown to inhibit the...
Anwendung: | TRPA1 agonist |
MW: | 162,27 D |
ab 542,00 €
Artikelnummer: Cay28915-5
PF-4840154 is a transient receptor potential ankyrin 1 (TRPA1) agonist. It induces calcium influx into HEK293 cells expressing recombinant human or rat TRPA1 (EC50s = 23 and 97 nM, respectively). Intraplantar injection of PF-4840154 (30 nmol) increases paw licking time in mice in a TRPA1-dependent manner.Formal...
Schlagworte: | 4-[(2-methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide |
Anwendung: | TRPA1 agonist |
CAS | 1332708-14-1 |
MW: | 466.6 D |
ab 43,00 €
Artikelnummer: Cay21019-10
Supercinnamaldehyde is an activator of the transient receptor potential ankyrin 1 (TRPA1) channel (EC50 = 0.8 µM) and an analog of cinnamaldehyde. TRPA1 is a nociceptor expressed on sensory neurons and is activated by hot and cold temperatures, mechanical stimuli, and pain.Formal Name:...
Schlagworte: | 1,3-dihydro-1-methyl-3-(2-oxopropylidene)-2H-indol-2-one |
Anwendung: | TRPA1 activator |
CAS | 70351-51-8 |
MW: | 201.2 D |
ab 42,00 €
Artikelnummer: Cay11912-10
AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 µM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.Formal Name: 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime. CAS Number:...
Schlagworte: | 4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime |
Anwendung: | TRPA1 inhibitor |
CAS | 55224-94-7 |
MW: | 209.7 D |
ab 77,00 €
Artikelnummer: Cay14979-5
Polygodial is a sesquiterpene dialdehyde isolated from the leaves of certain peppers and related plants. Noted for its broad antifungal properties, polygodial is also cytotoxic against bacteria, algae, and sea squirts. In mammals, polygodial produces a pungent flavor, activates the transient receptor potential...
Schlagworte: | Tadeonal, (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde |
Anwendung: | TRPA1 agonist |
CAS | 6754-20-7 |
MW: | 234.3 D |
ab 43,00 €
Artikelnummer: Cay29732-1
JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 µM.Formal Name:...
Schlagworte: | 2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-acetamide |
Anwendung: | TRPA1 agonist |
CAS | 917562-33-5 |
MW: | 354.9 D |
ab 52,00 €
Artikelnummer: AG-CN2-0085-M010
Isolated from Umbellularia californica Nutt. Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and...
Schlagworte: | (-)-Umbellulone, Umbellol, NSC 22046, BRN 2042730, Oreodaphnol, 3-Thujen-2-one |
Anwendung: | Selective TRPA1 activator |
CAS | 546-78-1 |
MW: | 150,2 D |
ab 165,00 €
Artikelnummer: Cay14851-10
Optovin is a TRPA1 ligand that can be reversibly photoactivated by violet (405 nm) light. Optovin-treated zebrafish respond to light with vigorous motor excitation (EC50 = 2 µM). Optovin-treated mouse dorsal root ganglia neurons displayed increased intracellular calcium following stimulation with light but only in...
Schlagworte: | 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone |
Anwendung: | Photoactivatable TRPA1 ligand |
CAS | 348575-88-2 |
MW: | 315.4 D |
ab 109,00 €