TAS 116

TAS 116 is a heat shock protein 90 (Hsp90) inhibitor. It selectively binds to Hsp90alpha and Hsp90beta (Kis = 34.7 and 21.3 nM, respectively) over glucose-regulated protein 94 (GRP94) and TGF-beta receptor-associated protein 1 (TRAP1, Kis = 50,000 nM for both). TAS 116 (3.6, 7.1, and 14 mg/kg) reduces intratumoral protein levels of HER2, HER3, and Akt, as well as reduces tumor growth in a HER2-expressing NCI N87 gastric cancer mouse xenograft model and does not induce photoreceptor injury in rats when administered at a dose of 12 mg/kg per day.Formal Name: 3-ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-benzamide. CAS Number: 1260533-36-5. Molecular Formula: C25H26N8O. Formula Weight: 454.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(C1=CC=C(N2N=C(C(C)C)C3=C(N4C=NC(C5=CN(C)N=C5)=C4)C=CN=C32)C(CC)=C1)N. InChi Code: InChI=1S/C25H26N8O/c1-5-16-10-17(24(26)34)6-7-20(16)33-25-22(23(30-33)15(2)3)21(8-9-27-25)32-13-19(28-14-32)18-11-29-31(4)12-18/h6-15H,5H2,1-4H3,(H2,26,34). InChi Key: NVVPMZUGELHVMH-UHFFFAOYSA-N.