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Pimitespib
Artikelnummer: TGM-T16994-10mg
Description: Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90alpha/HSP90beta inhibitor with inhibition constants (Kis) of 34.7 nM and 21.3 nM, respectively. Target: HSP. Smiles: CCc1cc(ccc1-n1nc(C(C)C)c2c(ccnc12)-n1cnc(c1)-c1cnn(C)c1)C(N)=O. References: Ohkubo S, et al. TAS-116, a highly...
| Schlagworte: | TAS-116 |
| Anwendung: | Hsp90 inhibitor |
| CAS | 1260533-36-5 |
| MW: | 454.53 D |
ab 34,00 €
TAS 116
Artikelnummer: Cay33779-10
TAS 116 is a heat shock protein 90 (Hsp90) inhibitor. It selectively binds to Hsp90alpha and Hsp90beta (Kis = 34.7 and 21.3 nM, respectively) over glucose-regulated protein 94 (GRP94) and TGF-beta receptor-associated protein 1 (TRAP1, Kis = 50,000 nM for both). TAS 116 (3.6, 7.1, and 14 mg/kg) reduces intratumoral...
| Schlagworte: | 3-ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]-benzamide |
| Anwendung: | Hsp90 inhibitor |
| CAS | 1260533-36-5 |
| MW: | 454.5 D |
ab 128,00 €
