Zu "K09487" wurden 103 Artikel gefunden!
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KUNB31
Artikelnummer: AG-CR1-3758-M001
KUNB31 is an isoform-selective potent inhibitor of HSP90beta with an IC50 value of 180 nM and > 50-fold selectivity over the isoforms HSP90alpha and GRP94. KUNB31 was shown to induce the degradation of HSP90beta-dependent client proteins, but not those of Hsp90alpha and GRP94. It showed anti-proliferative activity...
| Schlagworte: | (4-Hydroxy-7-isopropylbenzo[d]isoxazol-5-yl)(isoindolin-2-yl)methanone |
| Anwendung: | Isoform-selective potent HSP90beta inhibitor |
| CAS | 2220263-80-7 |
| MW: | 322,4 D |
77,00 €
HSP90B1 (human), recombinant protein
Artikelnummer: ABS-PP-176.20
| Schlagworte: | Endoplasmin, 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1,... |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 68 kD |
ab 90,00 €
PF04929113
Artikelnummer: TGM-T6341-100mg
Description: PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF04929113 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers. Target: HSP, HER. Smiles:...
| Schlagworte: | SNX-5422, PF 04929113, PF-04929113 |
| Anwendung: | Hsp90 inhibitor prodrug |
| CAS | 908115-27-5 |
| MW: | 521.53 D |
ab 34,00 €
Pimitespib
Artikelnummer: TGM-T16994-10mg
Description: Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90alpha/HSP90beta inhibitor with inhibition constants (Kis) of 34.7 nM and 21.3 nM, respectively. Target: HSP. Smiles: CCc1cc(ccc1-n1nc(C(C)C)c2c(ccnc12)-n1cnc(c1)-c1cnn(C)c1)C(N)=O. References: Ohkubo S, et al. TAS-116, a highly...
| Schlagworte: | TAS-116 |
| Anwendung: | Hsp90 inhibitor |
| CAS | 1260533-36-5 |
| MW: | 454.53 D |
ab 34,00 €
VER-82576
Artikelnummer: TGM-T2114-100mg
Description: VER-82576 (NVP-BEP800), a synthetic HSP90beta inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94. Target: HSP. Smiles: CCNC(=O)c1cc2c(nc(N)nc2s1)-c1cc(OCCN2CCCC2)c(Cl)cc1Cl. References: Massey AJ, et al. Mol Cancer Ther, 2010, 9(4), 906-919.
| Schlagworte: | NVP-BEP800 |
| Anwendung: | Hsp90 beta inhibitor |
| CAS | 847559-80-2 |
| MW: | 480.41 D |
ab 40,00 €
NVP-HSP990
Artikelnummer: TGM-T6118-100mg
Description: NVP-HSP990 (HSP990) is an effective and specific HSP90alpha/beta inhibitor (IC50: 0.6 /0.8 nM). Target: Apoptosis, HSP. Smiles: COC1=CC=CC(=N1)C1=C(C=CC(F)=C1)C1CC2=C(C(C)=NC(N)=N2)C(=O)N1. References: Menezes DL, et al. Mol Cancer Ther, 2012, 11(3), 730-739.
| Schlagworte: | HSP990 |
| Anwendung: | Hsp90 inhibitor |
| CAS | 934343-74-5 |
| MW: | 379.39 D |
ab 42,00 €
XL888
Artikelnummer: TGM-T6248-100mg
Description: XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis. Through this action, specific client proteins are degraded, resulting in cell cycle...
| Anwendung: | Hsp90 inhibitor |
| CAS | 1149705-71-4 |
| MW: | 503.64 D |
ab 43,00 €
Grp94 Inhibitor-1
Artikelnummer: TGM-T7261-100mg
Description: Grp94 Inhibitor-1 is a potent and selective inhibitor of Grp94 with an IC50 of 2 nM. Target: HSP, GPR. Smiles: CC(C)c1ccc(cc1)-c1ccc(N[C@H]2CC[C@H](O)CC2)c(c1)C(N)=O. References: Jiang F , Guo A P , Xu J C , et al. Discovery of a Potent Grp94 Selective Inhibitor with Anti-inflammatory Efficacy in a...
| Anwendung: | Grp94 inhibitor |
| CAS | 2234897-35-7 |
| MW: | 352.47 D |
ab 42,00 €
Anti-HSP90B1
Artikelnummer: CSB-PA002347.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-GRP94, Anti-GRP-94, Anti-Endoplasmin, Anti-gp96 homolog, Anti-Tumor rejection antigen 1, Anti-94 kDa... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 126,00 €
Anti-HSP90B1
Artikelnummer: CSB-PA088395.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: HSP90B1. Antigen Species: Human
| Schlagworte: | Anti-GRP94, Anti-GRP-94, Anti-Endoplasmin, Anti-gp96 homolog, Anti-Tumor rejection antigen 1, Anti-94 kDa... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €
Anti-HSP90B1
Artikelnummer: CSB-PA10887A0Rb.100
Host Species: Rabbit. Isotype: IgG. Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: >95%, Protein G purified. Target Name: HSP90B1. Antigen Species: Human
| Schlagworte: | Anti-GRP94, Anti-GRP-94, Anti-Endoplasmin, Anti-gp96 homolog, Anti-Tumor rejection antigen 1, Anti-94 kDa... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 167,00 €
Anti-HSP90B1
Artikelnummer: CSB-PA179036.100
Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: HSP90B1. Antigen Species: Human
| Schlagworte: | Anti-GRP94, Anti-GRP-94, Anti-Endoplasmin, Anti-gp96 homolog, Anti-Tumor rejection antigen 1, Anti-94 kDa... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 167,00 €