Talotrexin ammonium

Description: Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, helping to inhibit tumor growth. Target: DHFR. Smiles: NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCCNC(=O)C4=C(C(O)=O)C=CC=C4)C(O)=O)=O)C=C3)=N2)N=C(N)N1.N. References: C S Rocha Lima, et al. A phase I study of talotrexin (PT-523) in patients with relapsed or refractory non-small cell lung cancer (NSCLC).