Zu "K00287" wurden 76 Artikel gefunden!
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Methotrexate (hydrate)
Artikelnummer: Cay13960-50
Methotrexate (MTX) is similar in structure to folic acid (Cay-20515) and aminopterin (Cay-21802). It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of...
| Schlagworte: | Amethopterin, CL 14,377, EMT 25299, MTX, NSC 740, R 9985,... |
| Anwendung: | Antineoplastic agent, dihydrofolate reductase inhibitor |
| CAS | 133073-73-1 |
| MW: | 454.4 D |
ab 38,00 €
Anti-DHFR
Artikelnummer: ATA-HPA042478.100
Rabbit Polyclonal DHFR Antibody against Human dihydrofolate reductase. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000021707: 90%, ENSRNOG00000013521:...
| Schlagworte: | Anti-DHFR, EC=1.5.1.3, Anti-Dihydrofolate reductase |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Aminopterin
Artikelnummer: Cay21802-50
Aminopterin is a synthetic folic acid (Cay-20515) derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though...
| Schlagworte: | 4-amino Folic Acid, 4-amino PGA, APGA, NSC 739, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid |
| Anwendung: | Dihydrofolate reductase inhibitor prodrug |
| CAS | 54-62-6 |
| MW: | 440.4 D |
ab 49,00 €
Methotrexate-d3
Artikelnummer: Cay22378-1
Methotrexate-d3 is intended for use as an internal standard for the quantification of MTX (Cay-13960) by GC- or LC-MS. MTX is similar in structure to folic acid (Cay-20515) and aminopterin (Cay-21802). It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and...
| Schlagworte: | Amethopterin-d3, MTX-d3, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methyl-d3-amino]benzoyl]-L-glutamic acid |
| Anwendung: | GC-MS, LC-MS, internal standard, DHFR inhibitor |
| CAS | 432545-63-6 |
| MW: | 457.5 D |
ab 93,00 €
Methotrexate
Artikelnummer: TGM-T1485-50mg
Description: Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors. Target: DNA/RNA Synthesis, Dehydrogenase, Apoptosis, ADC...
| Schlagworte: | Amethopterin, CL14377, NCI-C04671, WR19039 |
| Anwendung: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 59-05-2 |
| MW: | 454.44 D |
ab 37,00 €
Anti-DHFR, clone 5B2
Artikelnummer: ARG57150.50
Protein function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. [The UniProt Consortium]
| Schlagworte: | Anti-DHFR, EC=1.5.1.3, Anti-Dihydrofolate reductase |
| Anwendung: | WB, FC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
518,00 €
Human Dihydrofolate Reductase / DHFR ELISA Kit
Artikelnummer: G-HUFI02107.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-DHFR
Artikelnummer: NSJ-R31590
0.5mg/ml if reconstituted with 0.2ml sterile DI water.
| Schlagworte: | Anti-DHFR, EC=1.5.1.3, Anti-Dihydrofolate reductase, DHFR Antibody |
| Anwendung: | WB, IHC (paraffin), IF, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
Pralatrexate
Artikelnummer: Cay23689-10
Pralatrexate is a dihydrofolate reductase (DHFR) inhibitor (Ki = 13.4 pM) and antifolate. It inhibits growth of CCRF-CEM acute lymphocytic leukemia cells (IC50 = 0.04 µM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 µM, respectively), and SK-LC8 and SK-LC16 non-small cell lung...
| Schlagworte: | 10-Propargyl-10-deazaaminopterin, NSC 754230, PDX,... |
| Anwendung: | Dihydrofolate reductase (DHFR) inhibitor |
| CAS | 146464-95-1 |
| MW: | 477.5 D |
ab 541,00 €
Anti-DHFR
Artikelnummer: NSJ-F52556-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. Protein function:...
| Schlagworte: | Anti-DHFR, EC=1.5.1.3, Anti-Dihydrofolate reductase, DHFR Antibody |
| Anwendung: | IHC, WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 361,00 €
Trimethoprim sulfate
Artikelnummer: CDX-T0146-M025
White powder. Soluble in water. Antibacterial compound. Pyrimidine inhibitor of dihydrofolate reductase.
| Schlagworte: | 2,4-Pyrimidinediamine, 5-((3,4-trimethoxyphenyl)methyl)-, sulfate (2:1), BW 72U |
| Anwendung: | Antibacterial compound, Dihydrofolate reductase inhibitor |
| CAS | 56585-33-2 |
| MW: | 678,24 D |
ab 138,00 €
Anti-DHFR
Artikelnummer: ARG58075.100
Protein function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. [The UniProt Consortium]
| Schlagworte: | Anti-DHFR, EC=1.5.1.3, Anti-Dihydrofolate reductase |
| Anwendung: | ICC, IF, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
707,00 €