Zu "K00287" wurden 73 Artikel gefunden!
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Methotrexate (hydrate)
Artikelnummer: Cay13960-50
Methotrexate (MTX) is similar in structure to folic acid (Cay-20515) and aminopterin (Cay-21802). It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of...
| Schlagworte: | Amethopterin, CL 14,377, EMT 25299, MTX, NSC 740, R 9985,... |
| Anwendung: | Antineoplastic agent, dihydrofolate reductase inhibitor |
| CAS | 133073-73-1 |
| MW: | 454.4 D |
ab 35,00 €
Dihydrofolate reductase Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-01224-100ug
Description: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
| Schlagworte: | Dihydrofolate reductase, DHFR |
| MW: | 25.5 kD |
ab 198,00 €
Dihydrofolate reductase Protein, S. aureus, Recombinant...
Artikelnummer: TGM-TMPH-03535-100ug
Description: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular...
| Schlagworte: | folA, Dihydrofolate reductase, DHFR |
| MW: | 25.6 kD |
ab 359,00 €
Dihydrofolate reductase Protein, S. epidermidis,...
Artikelnummer: TGM-TMPH-03581-100ug
Description: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is...
| Schlagworte: | folA1, dfrC, Dihydrofolate reductase, DHFR, folA |
| MW: | 22.0 kD |
ab 359,00 €
Dihydrofolate reductase Protein, E. coli, Recombinant (His)
Artikelnummer: TGM-TMPH-00608-100ug
Description: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
| Schlagworte: | folA, tmrA, Dihydrofolate reductase |
| MW: | 18.8 kD |
ab 281,00 €
Methotrexate-d3
Artikelnummer: TGM-TMIH-0335-1mg
Description: Methotrexate-d3 is a deuterated compound of Methotrexate. Methotrexate has a CAS number of 59-05-2. Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties. Target: ADC Cytotoxin. Smiles:...
| Anwendung: | GC-MS, LC-MS, internal standard, DHFR inhibitor |
| CAS | 432545-63-6 |
| MW: | 457.46 D |
ab 287,00 €
Pemetrexed tromethamine
Artikelnummer: TGM-T25929-100mg
Description: Pemetrexed tromethamine is a chemotherapy drug used for pleural mesothelioma and non-small cell lung cancer. Target: Others. Smiles: OCC(CO)(N)CO.OC(CC[C@@H](C(O)=O)NC(C(C=C1)=CC=C1CCC2=CNC(NC(N)=N3)=C2C3=O)=O)=O.OCC(CO)(N)CO.O.O. References: Lin L, Zhao J, Hu J, Zou G, Huang F, Han J, He Y, Cao X....
| Schlagworte: | Pemetrexed ditromethamine dihydrate |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 1851348-04-3 |
| MW: | 705.72 D |
ab 1.520,00 €
Talotrexin ammonium
Artikelnummer: TGM-T64295-100mg
Description: Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, helping to inhibit tumor growth. Target: DHFR. Smiles:...
| Anwendung: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 648420-92-2 |
| MW: | 590.59 D |
ab 348,00 €
Trimetrexate glucuronate
Artikelnummer: TGM-T63985-100mg
Description: Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist that inhibits dihydrofolate reductase, blocking the synthesis of purine nucleotides and thymidylic acid, therefore affecting DNA and RNA synthesis and exhibiting potential anti-tumour effects. Target: Others. Smiles:...
| Anwendung: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 82952-64-5 |
| MW: | 563.564 D |
Bitte fragen Sie den aktuellen Preis für diesen Artikel an.
Pemetrexed disodium hemipenta hydrate
Artikelnummer: TGM-T6226-100mg
Description: Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 65 nM, respectively. Target: Apoptosis, DNA/RNA Synthesis, Autophagy, DHFR,...
| Schlagworte: | Pemetrexed sodium hydrate, LY-231514 Disodium Hydrate, Pemetrexed Disodium Hydrate |
| Anwendung: | Targets thymidylate synthase [EC:2.1.1.45] (thyA, TYMS) |
| CAS | 357166-30-4 |
| MW: | 518.43 D |
ab 34,00 €
Trimetrexate
Artikelnummer: TGM-T17164-100mg
Description: Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase. Target: Others. Smiles: COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC
| Schlagworte: | CI-898 |
| Anwendung: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 52128-35-5 |
| MW: | 369.42 D |
Bitte fragen Sie den aktuellen Preis für diesen Artikel an.
Methotrexate
Artikelnummer: TGM-T1485-100mg
Description: Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors. Target: DNA/RNA Synthesis, Dehydrogenase, Apoptosis, ADC...
| Schlagworte: | Amethopterin, CL14377, NCI-C04671, WR19039 |
| Anwendung: | Targets dihydrofolate reductase [EC:1.5.1.3] (DHFR, folA) |
| CAS | 59-05-2 |
| MW: | 454.44 D |
ab 40,00 €