Syk Inhibitor

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcepsilonRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM). At 2 µM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.Formal Name: 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide. CAS Number: 622387-85-3. Synonyms: OXSI 2, Spleen Tyrosine Kinase. Molecular Formula: C18H15N3O3S. Formula Weight: 353.4. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. lambdamax: 223, 279, 428 nm. SMILES: [H]N(C1=C(/C2=C/C3=CN(C)C4=C3C=CC=C4)C=C(S(=O)(N)=O)C=C1)C2=O. InChi Code: InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-. InChi Key: MLKHXLFEYOOYEY-NVNXTCNLSA-N.