Zu "K05855" wurden 115 Artikel gefunden!
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R788 (sodium salt)
Artikelnummer: Cay18501-5
R788 is a prodrug of R406 (Cay-11422), an inhibitor of Syk (Ki = 30 nM). R788 conversion to the biologically active R406 is catalyzed by the action of alkaline phosphatases present on the apical brush-border of the membranes of intestinal enterocytes. It produces anti-inflammatory and immunomodulating effects by...
| Schlagworte: | Fostamatinib, NSC 745942, R935788, Tamatinib Fosdium,... |
| Anwendung: | Syk inhibitor/R406 prodrug |
| CAS | 1025687-58-4 |
| MW: | 624.4 D |
ab 61,00 €
Gusacitinib
Artikelnummer: LKT-G823720.100
Gusacitinib is a dual inhibitor of SYK/JAK kinases. SMILES: C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O
| Schlagworte: | ASN-002, ASN002,... |
| Anwendung: | SYK/JAK inhibitor |
| CAS | 1425381-60-7 |
| MW: | 460.54 D |
ab 115,00 €
RO9021
Artikelnummer: TGM-T16776-100mg
Description: RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor [average IC50: 5.6 nM]. Target: Syk. Smiles: Cc1ccc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)nc1C. References: Liao C, et al. Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor,...
| Anwendung: | Syk inhibitor |
| CAS | 1446790-62-0 |
| MW: | 355.44 D |
ab 79,00 €
TAK-659
Artikelnummer: TGM-T21062-25mg
Description: TAK-659 is a spleen tyrosine kinase (SYK) inhibitor. Target: Others. Smiles: O=C1C2=C(N=C(N[C@H]3[C@@H](N)CCCC3)C(F)=C2CN1)C=4C=NN(C)C4. References: Cen O, Kannan K, Huck Sappal J, Yu J, Zhang M, Arikan M, Ucur A, Ustek D, Cen Y, Gordon L, Longnecker R. Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents...
| Schlagworte: | TAK 659, TAK659 |
| Anwendung: | Targets spleen tyrosine kinase [EC:2.7.10.2] (SYK) |
| CAS | 1312691-33-0 |
| MW: | 344.39 D |
ab 1.820,00 €
OXSI-2
Artikelnummer: TGM-T28281-10mg
Description: OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets. Target: Syk. Smiles: C(=C1C=2C(NC1=O)=CC=C(S(N)(=O)=O)C2)C=3C=4C(N(C)C3)=CC=CC4. References: Badolia R,...
| Schlagworte: | Syk Inhibitor, OXSI 2 |
| Anwendung: | Spleen Tyrosine Kinase inhibitor |
| CAS | 622387-85-3 |
| MW: | 353.39 D |
ab 77,00 €
R112
Artikelnummer: TGM-T3185-100mg
Description: R112 is an ATP-competitive inhibitor of Syk kinase. Ki=6 nM,IC50=226 nM. Target: Syk. Smiles: Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1. References: Rossi AB, et al. J Allergy Clin Immunol. 2006 Sep,118(3):749-55.
| Schlagworte: | (E)-Elafibranor |
| Anwendung: | Syk inhibitor |
| CAS | 575474-82-7 |
| MW: | 312.3 D |
ab 34,00 €
Syk Inhibitor II
Artikelnummer: TGM-T4348-1mL
Description: Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM). Target: 5-HT Receptor, Syk. Smiles: NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1. References: Hisamichi H,etal.Synthetic studies on novel Syk inhibitors. Part 1:...
| Anwendung: | Syk inhibitor |
| CAS | 726695-51-8 |
| MW: | 340.3 D |
ab 42,00 €
Syk Inhibitor II dihydrochloride
Artikelnummer: TGM-T4391-100mg
Description: Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable,...
| Schlagworte: | Syk Inhibitor II (hydrochloride) |
| Anwendung: | Syk inhibitor |
| CAS | 227449-73-2 |
| MW: | 413.22 D |
ab 131,00 €
Fostamatinib
Artikelnummer: TGM-T6115-100mg
Description: Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn. Target: Monoamine Transporter, FLT, Adenosine Receptor, Syk. Smiles: COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP(O)(O)=O)c4n3)n2)cc(OC)c1OC. References: Braselmann S, et...
| Schlagworte: | R788 |
| Anwendung: | Targets spleen tyrosine kinase [EC:2.7.10.2] (SYK) |
| CAS | 901119-35-5 |
| MW: | 580.46 D |
ab 37,00 €
Syk Inhibitor II dihydrochloride dihydrate
Artikelnummer: TGM-T62691-100mg
Description: Syk Inhibitor II dihydrochloride dihydrate is a highly selective, potent, ATP-competitive Syk inhibitor (IC50: 41 nM) that exhibits anti-allergic effects. Target: Others. Smiles: O.O.Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
| Anwendung: | Syk inhibitor |
| CAS | 1965323-05-0 |
| MW: | 449.26 D |
ab 1.520,00 €
BAY 61-3606 HCl
Artikelnummer: TGM-T70377-10mg
Description: BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction,...
| Anwendung: | Cell-permeable, reversible Syk inhibitor |
| CAS | 1615197-10-8 |
| MW: | 426.86 D |
ab 142,00 €
MNS
Artikelnummer: TGM-T6594-100mg
Description: MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 µM, 29.3 µM and 1.7 µM, respectively. Target: p97, Syk, Src. Smiles: [O-][N+](=O)\C=C\c1ccc2OCOc2c1. References: Wang WY, et al. Mol Pharmacol, 2006, 70(4), 1380-1389.
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 1485-00-3 |
| MW: | 193.16 D |
ab 31,00 €