Zu "K05855" wurden 91 Artikel gefunden!
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Anti-SYK / Spleen tyrosine kinase
Artikelnummer: NSJ-F54945-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...
| Schlagworte: | Anti-SYK, Anti-p72-Syk, Anti-Spleen tyrosine kinase, Anti-Tyrosine-protein kinase SYK, SYK Antibody / Spleen tyrosine kinase |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 326,00 €
Anti-SYK / Spleen tyrosine kinase
Artikelnummer: NSJ-RQ5553
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Spleen tyrosine kinase, also known as Syk, is an enzyme which in humans is encoded by the SYK gene. It is mapped to 9q22.2. This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells...
| Schlagworte: | Anti-SYK, Anti-p72-Syk, Anti-Spleen tyrosine kinase, Anti-Tyrosine-protein kinase SYK, SYK Antibody / Spleen tyrosine kinase |
| Anwendung: | WB, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Human SYK (Spleen Tyrosine Kinase) ELISA Kit
Artikelnummer: ELK-ELK4273.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human SYK. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human SYK. Next,...
| Schlagworte: | SYK, p72-Syk, Spleen tyrosine kinase, Tyrosine-protein kinase SYK |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
SYK, catalytic, active human recombinant protein
Artikelnummer: BPS-40487
Recombinant human SYK, Genbank Accession # NM_003177, a.a. 359-635(end), expressed in Sf9 insect cells using an N-terminal GST tag. MW = 58 kDa. Assay conditions: SYK was incubated with a substrate (Tyr peptide 2) for 1 hr. at RT in 1X kinase buffer supplemented with ATP. Developer solution was added to reaction and...
| Schlagworte: | SYK, p72-Syk, Spleen tyrosine kinase, Tyrosine-protein kinase SYK, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 58 kD |
525,00 €
R406
Artikelnummer: Cay11422-1
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcepsilonRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 µM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce...
| Schlagworte: | 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one |
| Anwendung: | Potent ATP-competitive Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470.5 D |
ab 92,00 €
BAY 61-3606 (hydrochloride)
Artikelnummer: Cay11423-1
BAY 61-3606 is an inhibitor of spleen tyrosine kinase (Syk, Ki = 7.5 nM). It is selective for Syk over Lyn, Fyn, Src, Itk, and BTK (Kis = >4.7 µM for all). BAY 61-3606 inhibits anti-IgE-induced histamine release in isolated human mast cells sensitized with IgE (IC50 = 5.1 nM), as well as reduces anti-IgM-induced...
| Schlagworte: | 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide, monohydrochloride |
| Anwendung: | Cell-permeable, reversible Syk inhibitor |
| CAS | 1615197-10-8 |
| MW: | 426.9 D |
ab 77,00 €
R788 (sodium salt)
Artikelnummer: Cay18501-5
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. R788 is a prodrug of R406 (Cay-11422), an inhibitor of Syk (Ki = 30...
| Schlagworte: | Fostamatinib, NSC 745942, R935788, Tamatinib Fosdium,... |
| Anwendung: | R406 prodrug, Syk inhibitor |
| CAS | 1025687-58-4 |
| MW: | 624.4 D |
ab 60,00 €
MNS
Artikelnummer: Cay15206-10
MNS is a beta-nitrostyrene that blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619 (Cay-16450), and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively). It reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM,...
| Schlagworte: | 3,4-Methylenedioxy-beta-nitrostyrene, NSC 10120, NSC 105303, NSC 170724, Syk Inhibitor III,... |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 1485-00-3 |
| MW: | 193.2 D |
ab 65,00 €
Anti-SYK (IHC)
Artikelnummer: IHC-00443
Protein function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation,...
| Schlagworte: | Anti-SYK, Anti-p72-Syk, EC=2.7.10.2, Anti-Spleen tyrosine kinase, Anti-Tyrosine-protein kinase SYK |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
Piceatannol
Artikelnummer: AG-CN2-0086-M001
Synthetic. Originally isolated from Euphorbia lagascae. Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB...
| Schlagworte: | CCRIS 9289, NSC365798, NSC622471, 3,3',4,5'-Tetrahydroxy-trans-stilbene, 3-Hydroxyresveratrol |
| Anwendung: | Tyrosine and serine/threonine protein kinase inhibitor |
| CAS | 10083-24-6 |
| MW: | 244,3 D |
ab 33,00 €
BIIB-057
Artikelnummer: Cay17652-5
BIIB-057 is a potent inhibitor of the non-receptor tyrosine kinase Syk (IC50 = 1 nM). It displays at least 80-fold selectivity for Syk over other kinases. BIIB-057 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC50s = 0.27 and 0.28 µM, respectively), as well as Fc? receptor 1-mediated...
| Schlagworte: | P505-15, PRT062607, PRT2607,... |
| Anwendung: | Syk inhibitor |
| CAS | 1370261-96-3 |
| MW: | 393.5 D |
ab 73,00 €
GS-9973
Artikelnummer: Cay17653-1
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. GS-9973 is a potent Syk inhibitor (IC50 = 7.7 nM) that demonstrates...
| Schlagworte: | 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-imidazo[1,2-a]pyrazin-8-amine |
| Anwendung: | Syk inhibitor |
| CAS | 1229208-44-9 |
| MW: | 411.5 D |
ab 48,00 €