Zu "K05855" wurden 117 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Recombinant Syk, clone 5F3
Artikelnummer: E-AN301367L.100
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and...
| Schlagworte: | Anti-SYK, Anti-p72-Syk, Anti-Spleen tyrosine kinase, Anti-Tyrosine-protein kinase SYK, Recombinant Syk Monoclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
391,00 €
SYK, catalytic, active human recombinant protein
Artikelnummer: BPS-40487
Recombinant human SYK, Genbank Accession # NM_003177, a.a. 359-635(end), expressed in Sf9 insect cells using an N-terminal GST tag. MW = 58 kDa. Assay conditions: SYK was incubated with a substrate (Tyr peptide 2) for 1 hr. at RT in 1X kinase buffer supplemented with ATP. Developer solution was added to reaction and...
| Schlagworte: | SYK, p72-Syk, Spleen tyrosine kinase, Tyrosine-protein kinase SYK, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | human |
| MW: | 58 kD |
536,00 €
R406
Artikelnummer: Cay11422-1
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcepsilonRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 µM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce...
| Schlagworte: | 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one |
| Anwendung: | Potent ATP-competitive Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470.5 D |
ab 102,00 €
BAY 61-3606 (hydrochloride)
Artikelnummer: Cay11423-1
BAY 61-3606 is an inhibitor of spleen tyrosine kinase (Syk, Ki = 7.5 nM). It is selective for Syk over Lyn, Fyn, Src, Itk, and BTK (Kis = >4.7 µM for all). BAY 61-3606 inhibits anti-IgE-induced histamine release in isolated human mast cells sensitized with IgE (IC50 = 5.1 nM), as well as reduces anti-IgM-induced...
| Schlagworte: | 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide, monohydrochloride |
| Anwendung: | Cell-permeable, reversible Syk inhibitor |
| CAS | 1615197-10-8 |
| MW: | 426.9 D |
ab 85,00 €
MNS
Artikelnummer: Cay15206-10
MNS is a beta-nitrostyrene that blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619 (Cay-16450), and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively). It reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM,...
| Schlagworte: | 3,4-Methylenedioxy-beta-nitrostyrene, NSC 10120, NSC 105303, NSC 170724, Syk Inhibitor III,... |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 1485-00-3 |
| MW: | 193.2 D |
ab 72,00 €
Anti-SYK (IHC)
Artikelnummer: IHC-00443
Protein function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation,...
| Schlagworte: | Anti-SYK, Anti-p72-Syk, EC=2.7.10.2, Anti-Spleen tyrosine kinase, Anti-Tyrosine-protein kinase SYK |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Piceatannol
Artikelnummer: AG-CN2-0086-M001
Synthetic. Originally isolated from Euphorbia lagascae. Wide range of tyrosine and serine/threonine protein kinase inhibitor, including Syk, p56lck, PKA, PKC, MLCK, CDPK, JNK and PI3K. Inhibits the tyrosine phosphorylation of STAT3 and STAT5. Potent apoptosis inducer. Potent anticancer compound. Suppresses NF-kB...
| Schlagworte: | CCRIS 9289, NSC365798, NSC622471, 3,3',4,5'-Tetrahydroxy-trans-stilbene, 3-Hydroxyresveratrol |
| Anwendung: | Tyrosine and serine/threonine protein kinase inhibitor |
| CAS | 10083-24-6 |
| MW: | 244,3 D |
ab 33,00 €
BIIB-057
Artikelnummer: Cay17652-10
BIIB-057 is a potent inhibitor of the non-receptor tyrosine kinase Syk (IC50 = 1 nM). It displays at least 80-fold selectivity for Syk over other kinases. BIIB-057 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC50s = 0.27 and 0.28 µM, respectively), as well as Fc? receptor 1-mediated...
| Schlagworte: | P505-15, PRT062607, PRT2607,... |
| Anwendung: | Syk inhibitor |
| CAS | 1370261-96-3 |
| MW: | 393.5 D |
ab 81,00 €
GS-9973
Artikelnummer: Cay17653-1
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. GS-9973 is a potent Syk inhibitor (IC50 = 7.7 nM) that demonstrates...
| Schlagworte: | 6-(1H-indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]-imidazo[1,2-a]pyrazin-8-amine |
| Anwendung: | Syk inhibitor |
| CAS | 1229208-44-9 |
| MW: | 411.5 D |
ab 54,00 €
R788 disodium salt
Artikelnummer: SYN-1122-M001
Slightly soluble (<1mg/ml) in DMSO or ethanol. Tamatinib effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals. Target: BCR , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | Fostamatinib, Tamatinib fosdium, FosD, R-788 |
| Anwendung: | Syk inhibitor |
| CAS | 1025687-58-4 |
| MW: | 624,5 D |
ab 162,00 €
Syk Inhibitor
Artikelnummer: Cay14829-1
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRgamma chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk...
| Schlagworte: | OXSI 2, Spleen Tyrosine Kinase, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide |
| Anwendung: | Spleen Tyrosine Kinase inhibitor |
| CAS | 622387-85-3 |
| MW: | 353.4 D |
ab 49,00 €
PRT-060318
Artikelnummer: TGM-T6957-1mg
Description: PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment. Target: Syk. Smiles: Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1. References: Reilly MP, et al. Blood. 2011, 117(7):2241-2246.
| Schlagworte: | PRT-060318 2HCl, PRT318, P142-76 |
| Anwendung: | Syk inhibitor |
| CAS | 1194961-19-7 |
| MW: | 340.42 D |
ab 34,00 €