SR3335

Description: SR3335 (ML 176) is a selective inverse agonist of RORalpha that competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM). Target: ROR. Smiles: OC(c1ccc(NS(=O)(=O)c2cccs2)cc1)(C(F)(F)F)C(F)(F)F. References: Sadeghi H, et al. The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita. J Pathol. 2015 Sep,237(1):111-22.