SR 3335

The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORalpha, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It is without effect on RORbeta, RORgamma, farnesoid X receptor, or liver X receptor alpha. SR 3335 evokes RORalpha-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis.Formal Name: N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide. CAS Number: 293753-05-6. Synonyms: ML 176. Molecular Formula: C13H9F6NO3S2. Formula Weight: 405.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 16 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 231 nm. SMILES: OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(NS(C2=CC=CS2)(=O)=O)C=C1. InChi Code: InChI=1S/C13H9F6NO3S2/c14-12(15,16)11(21,13(17,18)19)8-3-5-9(6-4-8)20-25(22,23)10-2-1-7-24-10/h1-7,20-21H. InChi Key: LZWUNZRMANFRAO-UHFFFAOYSA-N. License: Sold under license from The Scripps Research Institute..