SP-141

Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP-141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP-141 promotes its auto-ubiquitination and proteasomal degradation. SP-141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.Formal Name: 6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole. CAS Number: 1253491-42-7. Synonyms: AGN-PC-0D106I. Molecular Formula: C22H16N2O. Formula Weight: 324.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 100 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 221, 300, 365 nm. SMILES: COC1=CC2=C(C=C1)NC(C2=CC=N3)=C3C4=C(C=CC=C5)C5=CC=C4. InChi Code: InChI=1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3. InChi Key: AABFWJDLCCDJJN-UHFFFAOYSA-N.