Zu "K06643" wurden 178 Artikel gefunden!
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(±)-Nutlin-3
Artikelnummer: Cay10004372-5
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585) and its less active enantiomer (+)-nutlin-3 (Cay-10009816). In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.Formal Name:...
| Schlagworte: | rel-4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-pi... |
| Anwendung: | Cell cycle arrest promotor |
| CAS | 548472-68-0 |
| MW: | 581.5 D |
ab 57,00 €
Anti-phospho-MDM2 (Ser166), clone 29M35
Artikelnummer: NSJ-RQ8702
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Phosphorylated MDM2 is a post-translationally modified form of the MDM2 protein, an E3 ubiquitin ligase that regulates the stability and activity of the tumor suppressor p53. Phosphorylation of MDM2 at specific residues modulates its...
| Schlagworte: | Anti-phospho-MDM2, Anti-phospho-Oncoprotein Mdm2, Anti-phospho-Double minute 2 protein, Anti-phospho-p53-binding protein... |
| Anwendung: | WB, IF, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
BI-907828
Artikelnummer: Cay44353-1
BI-907828 is an inhibitor of the protein-protein interaction between p53 and murine double minute 2 (MDM2, IC50 = 2 nM in a cell-free assay). It is selective for the p53-MDM2 interaction over the p53-MDMX interaction (IC50 = 7,944 nM). BI-907828 selectively inhibits the proliferation of Colon-26 colon cancer cells,...
| Schlagworte: | Brigimadlin, (2'S,3'S,... |
| Anwendung: | p53-MDM2 protein-protein interaction inhibitor |
| CAS | 2095116-40-6 |
| MW: | 591,46 D |
ab 64,00 €
(-)-Nutlin-3
Artikelnummer: Cay18585-1
(-)-Nutlin-3 is an inhibitor of the protein-protein interaction between p53 and Mdm2 (IC50 = 0.09 µM). It increases p53 levels, induces apoptosis, and reduces cell viability in HCT116, SJSA-1, and RKO cells that express wild-type p53 but not MDA-MB-435 or SW480 cells expressing mutant p53. (-)-Nutlin-3 (200 mg/kg)...
| Schlagworte: | Nutlin 3a,... |
| Anwendung: | Mdm2-p53 binding inhibitor |
| CAS | 675576-98-4 |
| MW: | 581.5 D |
ab 139,00 €
MD-224
Artikelnummer: Cay40960-1
A PROTAC that drives MDM2 degradation, induces degradation of MDM2, which increases p53 levels, in RS4,11 cells at 10 nM, inhibits the growth of RS4,11 cells (IC50 = 1.5 nM), induces complete tumor regression and does not affect body weight in an RS4,11 mouse xenograft model at 50 mg/kg every other day for three weeks
| Schlagworte: | (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-[4-[[[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol... |
| Anwendung: | MDM2 degradation driving PROTAC |
| CAS | 2136247-12-4 |
| MW: | 889.8 D |
ab 68,00 €
Anti-MDM2
Artikelnummer: ATA-HPA069791.100
Rabbit Polyclonal MDM2 Antibody against Human MDM2 proto-oncogene. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000020184: 88%, ENSRNOG00000006304: 84%....
| Schlagworte: | Anti-Hdm2, Anti-MDM2, Anti-Oncoprotein Mdm2, Anti-Double minute 2 protein, Anti-p53-binding protein Mdm2, Anti-E3... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
393,00 €
(+)-Nutlin-3
Artikelnummer: Cay10009816-5
(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585). It inhibits the interaction between p53 and Mdm2 150-fold less potently than (-)-nutlin-3 with an IC50 value of 13.6 µM. (+)-Nutlin-3 has been used as a negative control for the...
| Schlagworte: | Nutlin 3b,... |
| Anwendung: | Control |
| CAS | 675576-97-3 |
| MW: | 581.5 D |
ab 93,00 €
Caylin-2
Artikelnummer: Cay10005002-5
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116...
| Schlagworte: | 4-[4,5-bis(4-trifluoromethyl-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one |
| Anwendung: | Nutlin-3 analog |
| CAS | 1392830-09-9 |
| MW: | 648.6 D |
ab 115,00 €
Caylin-1
Artikelnummer: Cay10004985-5
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high...
| Schlagworte: | 4-[4,5-bis(3,4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one |
| Anwendung: | Nutlin-3 analog |
| CAS | 1207480-88-3 |
| MW: | 650.4 D |
ab 95,00 €
RG7388
Artikelnummer: Cay21532-1
RG7388 is a non-imidazoline, selective MDM2 inhibitor that blocks the binding of MDM2 to p53 (IC50 = 30 nM). By inhibiting MDM2, RG7388 activates the p53 pathway in SJSA1 osteosarcoma cells and inhibits the growth of xenografts in nude mice. RG7388 is orally available and prolonged daily administration results in...
| Schlagworte: | Idasanutlin, Ro 5503781,... |
| Anwendung: | MDM2 inhibitor |
| CAS | 1229705-06-9 |
| MW: | 616.5 D |
ab 71,00 €
Mdm2 E3 Ligase TR-FRET Kit
Artikelnummer: SBB-KF0030-KI01
South Bay Bio's MDM2 TR-FRET Ubiquitin Kit provides a fast and sensitive method monitoring ubiquitin conjugation onto GST-MDM2 in solution, resulting from an enzymatic ubiquitin cascade without the need of running and staining an SDS gel. The kit enables continuous TR-FRET detection of ubiquitin chain formation onto...
| Schlagworte: | MDM2, Hdm2, EC=2.3.2.27, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase... |
| Anwendung: | Enzyme assays |
| Spezies-Reaktivität: | human |
1.451,00 €
MDM2, GST-tag
Artikelnummer: BPS-100409
Recombinant human MDM2 (Mouse double minute 2 homolog), full length encompassing amino acids 2-498 (end). In this construct the N-terminal end of MDM2 is fused with GST. A short peptide linker placed between GST and the protein includes a PreScission Protease Cleavage Site to facilitate removal of the GST portion....
| Schlagworte: | Hdm2, MDM2, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2,... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 83 kD |
566,00 €