Zu "K06643" wurden 126 Artikel gefunden!
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(±)-Nutlin-3
Artikelnummer: Cay10004372-5
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585) and its less active enantiomer (+)-nutlin-3 (Cay-10009816). In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.Formal Name:...
| Schlagworte: | rel-4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-pi... |
| Anwendung: | Cell cycle arrest promotor |
| CAS | 548472-68-0 |
| MW: | 581.5 D |
ab 50,00 €
MDM2-Driven p53 Ubiquitination Assay Kit
Artikelnummer: BPS-82179
The MDM2-Driven p53 Ubiquitination Assay kit is a sensitive AlphaLisa(R) high-throughput screening (HTS) assay designed to measure MDM2 (mouse double minute 2 homolog) E3 ligase activity in a homogeneous 384 reaction format. The assay kit comes with enough biotinylated ubiquitin, ATP, FLAG-tagged p53, assay buffer,...
| Schlagworte: | Hdm2, MDM2, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2,... |
| Anwendung: | Inhibitor screening, drug discovery, HTS, IC50 determination, MDM2-driven ubiquitination studies |
| Spezies-Reaktivität: | human |
2.518,00 €
Mouse MDM2 (Mdm2 p53 Binding Protein Homolog) ELISA Kit
Artikelnummer: ELK-ELK6771.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse MDM2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse MDM2. Next,...
| Schlagworte: | Mdm2, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Human E3 ubiquitin-protein ligase Mdm2,MDM2 ELISA kit
Artikelnummer: ELK-ELK8761.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Mdm2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Mdm2. Next,...
| Schlagworte: | MDM2, Hdm2, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Human MDM2 (Mdm2 p53 Binding Protein Homolog) ELISA Kit
Artikelnummer: ELK-ELK4557.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MDM2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MDM2. Next,...
| Schlagworte: | MDM2, Hdm2, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
(-)-Nutlin-3
Artikelnummer: Cay18585-1
(-)-Nutlin-3 is an inhibitor of the protein-protein interaction between p53 and Mdm2 (IC50 = 0.09 µM). It increases p53 levels, induces apoptosis, and reduces cell viability in HCT116, SJSA-1, and RKO cells that express wild-type p53 but not MDA-MB-435 or SW480 cells expressing mutant p53. (-)-Nutlin-3 (200 mg/kg)...
| Schlagworte: | Nutlin 3a,... |
| Anwendung: | Mdm2-p53 binding inhibitor |
| CAS | 675576-98-4 |
| MW: | 581.5 D |
ab 125,00 €
(+)-Nutlin-3
Artikelnummer: Cay10009816-5
(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585). It inhibits the interaction between p53 and Mdm2 150-fold less potently than (-)-nutlin-3 with an IC50 value of 13.6 µM. (+)-Nutlin-3 has been used as a negative control for the...
| Schlagworte: | Nutlin 3b,... |
| Anwendung: | Control |
| CAS | 675576-97-3 |
| MW: | 581.5 D |
ab 84,00 €
Siremadlin
Artikelnummer: Cay38516-1
Siremadlin is an inhibitor of the protein-protein interaction between the E3 ubiquitin ligase MDM2 and p53 (IC50 = 0.21 nM). It selectively inhibits the MDM2-p53 protein-protein interaction over MDM4-p53, YAP1-TEAD4, PCSK9-LDLR, and Bcl-2-Bak interactions in time-resolved FRET (TR-FRET) assays (IC50s = 3.3, >150,...
| Schlagworte: | HDM201, NVP-HDM201,... |
| Anwendung: | MDM2-p53 protein-protein interaction inhibitor |
| CAS | 1448867-41-1 |
| MW: | 555.4 D |
ab 48,00 €
Caylin-2
Artikelnummer: Cay10005002-5
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116...
| Schlagworte: | 4-[4,5-bis(4-trifluoromethyl-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one |
| Anwendung: | Nutlin-3 analog |
| CAS | 1392830-09-9 |
| MW: | 648.6 D |
ab 104,00 €
Caylin-1
Artikelnummer: Cay10004985-5
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high...
| Schlagworte: | 4-[4,5-bis(3,4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carboxyl]-piperazin-2-one |
| Anwendung: | Nutlin-3 analog |
| CAS | 1207480-88-3 |
| MW: | 650.4 D |
ab 85,00 €
RG7388
Artikelnummer: Cay21532-1
RG7388 is a non-imidazoline, selective MDM2 inhibitor that blocks the binding of MDM2 to p53 (IC50 = 30 nM). By inhibiting MDM2, RG7388 activates the p53 pathway in SJSA1 osteosarcoma cells and inhibits the growth of xenografts in nude mice. RG7388 is orally available and prolonged daily administration results in...
| Schlagworte: | Idasanutlin, Ro 5503781,... |
| Anwendung: | MDM2 inhibitor |
| CAS | 1229705-06-9 |
| MW: | 616.5 D |
ab 64,00 €
Mdm2 E3 Ligase TR-FRET Kit
Artikelnummer: SBB-KF0030-KI01
South Bay Bio's MDM2 TR-FRET Ubiquitin Kit provides a fast and sensitive method monitoring ubiquitin conjugation onto GST-MDM2 in solution, resulting from an enzymatic ubiquitin cascade without the need of running and staining an SDS gel. The kit enables continuous TR-FRET detection of ubiquitin chain formation onto...
| Schlagworte: | MDM2, Hdm2, EC=2.3.2.27, Oncoprotein Mdm2, Double minute 2 protein, p53-binding protein Mdm2, E3 ubiquitin-protein ligase... |
| Anwendung: | Enzyme assays |
| Spezies-Reaktivität: | human |
1.433,00 €