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SP-141
Artikelnummer: Cay17003-1
Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP-141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP-141 promotes its auto-ubiquitination and proteasomal...
| Schlagworte: | AGN-PC-0D106I, 6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole |
| Anwendung: | Cell-permeable Mdm2 inhibitor |
| CAS | 1253491-42-7 |
| MW: | 324.4 D |
ab 67,00 €
SP-141
Artikelnummer: TGM-T21773-100mg
Description: SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. Target: Mdm2. Smiles: COc1ccc2[nH]c3c(nccc3c2c1)-c1cccc2ccccc12. References: Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer...
| Schlagworte: | SP 141 |
| CAS | 1253491-42-7 |
| MW: | 324.38 D |
ab 37,00 €
