Silmitasertib

Description: Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2, Ki: 0.38 nM). Target: Autophagy, Casein Kinase. Smiles: OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21. References: Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15,70(24):10288-98.