SHR0302

Description: SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2). Target: Apoptosis, JAK. Smiles: [H][C@@]12C[C@H](C[C@]1([H])CN(C2)C(=O)Nc1nc(OC)ns1)N(C)c1ncnc2[nH]ccc12. References: Gu Y J , Sun W Y , Zhang S , et al. Targeted blockade of JAK/STAT3 signaling inhibits proliferation, migration and collagen production as well as inducing the apoptosis of hepatic stellate cells[J]. International Journal of Molecular Medicine, 2016.