Zu "K11217" wurden 110 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-phospho-JAK1 (Tyr1034/1035), clone 31J16
Artikelnummer: NSJ-FY13168
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-JAK1 (Tyr1034/1035) antibody detects Janus kinase 1 phosphorylated at tyrosine residues 1034 and 1035, encoded by the JAK1 gene. Janus kinase 1 is a non-receptor tyrosine kinase that plays an...
| Schlagworte: | Anti-phospho-JAK1, Anti-phospho-Janus kinase 1, Anti-phospho-Tyrosine-protein kinase JAK1, Phospho-JAK1 (Tyr1034/1035)... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Lepzacitinib
Artikelnummer: Cay44278-1
Lepzacitinib is an inhibitor of JAK1 and JAK3 (IC50s = 1.5 and 3.6 nM, respectively). It selectively inhibits IL-2-induced activation of JAK1/3 over IFN-gamma-induced activation of JAK1/2, GM-CSF-induced activation of JAK2, and IL-12-induced activation of JAK2/tyrosine kinase 2 (TYK2) in isolated human peripheral...
| Schlagworte: | ATI-1777, 4-[[(3R)-1-(2-cyanoacetyl)-3-piperidinyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid, ethyl ester |
| Anwendung: | JAK1 / JAK3 inhibitor |
| CAS | 2321488-47-3 |
| MW: | 355,4 D |
ab 42,00 €
COVID-19 Forschung
Ruxolitinib
Artikelnummer: AG-CR1-3624-M005
White to off-white solid. Soluble in DMSO or ethanol. Insoluble in water. Antineoplastic, anti-inflammatory and immunomodulating agent, Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50 = 322nM), Affects DC...
| Schlagworte: | INCB018424, INC 424 |
| Anwendung: | JAK1 inhibitor, JAK2 inhibitor |
| CAS | 941678-49-5 |
| MW: | 306,4 D |
ab 72,00 €
SHR-0302
Artikelnummer: Cay42724-1
SHR-0302 is a JAK inhibitor (IC50s = 0. 0. and 7. nM for JAK1, -2, and -3, respectively). It is selective for these kinases over tyrosine kinase 2 (TYK2, IC50 = 42 nM). SHR-0302 inhibits the activation, proliferation, and TGF-beta-1-induced migration of HSC-T6 rat hepatic stellate cells when used at concentrations...
| Schlagworte: | Ivarmacitinib,... |
| Anwendung: | JAK inhibitor |
| CAS | 1445987-21-2 |
| MW: | 414.49 D |
ab 65,00 €
Filgotinib
Artikelnummer: Cay17669-5
Filgotinib is a JAK1 inhibitor (IC50 = 10 nM). It is selective for JAK1 over JAK3 (IC50 = 810 nM) but also inhibits JAK2 and tyrosine kinase 2 (Tyk2, IC50s = 28 and 116 nM, respectively), as well as Abl, FLT1, -3, and -4, FMS, Mer, and TBK1 activity by greater than 35% in a panel of 177 tyrosine kinases at 1 µM....
| Schlagworte: | GLPG0634,... |
| Anwendung: | JAK1 inhibitor |
| CAS | 1206161-97-8 |
| MW: | 425.5 D |
ab 84,00 €
Filgotinib-d4
Artikelnummer: Cay28875-1
Filgotinib-d4 is intended for use as an internal standard for the quantification of filgotinib (Cay-17669) by GC- or LC-MS. Filgotinib is a JAK1 inhibitor (IC50 = 10 nM). It is selective for JAK1 over JAK3 (IC50 = 810 nM) but also inhibits JAK2 and tyrosine kinase 2 (Tyk2, IC50s = 28 and 116 nM, respectively), as...
| Schlagworte: | GLPG0634-d4,... |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, JAK1 inhibitor |
| CAS | 2041095-50-3 |
| MW: | 429.5 D |
483,00 €
Upadacitinib
Artikelnummer: Cay29706-1
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM). It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2, IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 µM, but does inhibit JAK2, Rho-associated kinase I (ROCK1), and ROCK2 (IC50s = 120, 920, and 430 nM,...
| Schlagworte: | ABT-494, (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide |
| Anwendung: | JAK1 inhibitor |
| CAS | 1310726-60-3 |
| MW: | 380.4 D |
ab 49,00 €
CYT387
Artikelnummer: Cay16246-1
CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively). It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines....
| Schlagworte: | Momelotinib, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide |
| Anwendung: | JAK1 / JAK2 inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414.5 D |
ab 122,00 €
JAK Inhibitor I
Artikelnummer: Cay15146-5
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-gamma. JAK Inhibitor I is a pyridine-containing...
| Schlagworte: | CMP 6, Janus-Associated Kinase Inhibitor I, Pyridone 6,... |
| Anwendung: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.3 D |
ab 44,00 €
Oclacitinib
Artikelnummer: Cay18722-5
Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively). It is selective for JAK kinases over a panel of 38 additional kinases at 1 µM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-alpha levels in murine bone marrow-derived...
| Schlagworte: | PF-03394197, trans-N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanemethanesulfonamide |
| Anwendung: | JAK inhibitor |
| CAS | 1208319-26-9 |
| MW: | 337.4 D |
ab 52,00 €
Abrocitinib
Artikelnummer: Cay34869-1
Abrocitinib is a JAK1 inhibitor (IC50 = 0.029 µM). It is selective for JAK1 over JAK2, JAK3, and TYK2 (IC50s = 0.803, >10, and 1.253 µM, respectively) and a panel of 40 kinases at 1 µM. Abrocitinib inhibits IFN-alpha-, IL-21-, or IL-27-induced phosphorylation of STAT3 (IC50s = 0.189, 0.511, and 0.271 µM,...
| Schlagworte: | PF-04965842, N-[cis-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide |
| Anwendung: | JAK1 inhibitor |
| CAS | 1622902-68-4 |
| MW: | 323.4 D |
ab 44,00 €
Tofacitinib (citrate)
Artikelnummer: Cay11598-50
Tofacitinib is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively). It is selective for JAK1-3 over ROCK2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits...
| Schlagworte: | Tofacitinib citrate,... |
| Anwendung: | JAK inhibitor |
| CAS | 540737-29-9 |
| MW: | 504.5 D |
ab 102,00 €