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SHR-0302
Artikelnummer: Cay42724-1
SHR-0302 is a JAK inhibitor (IC50s = 0. 0. and 7. nM for JAK1, -2, and -3, respectively). It is selective for these kinases over tyrosine kinase 2 (TYK2, IC50 = 42 nM). SHR-0302 inhibits the activation, proliferation, and TGF-beta-1-induced migration of HSC-T6 rat hepatic stellate cells when used at concentrations...
| Schlagworte: | Ivarmacitinib,... |
| Anwendung: | JAK inhibitor |
| CAS | 1445987-21-2 |
| MW: | 414.49 D |
ab 65,00 €
SHR0302
Artikelnummer: TGM-T9195-100mg
Description: SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2). Target: Apoptosis, JAK. Smiles: [H][C@@]12C[C@H](C[C@]1([H])CN(C2)C(=O)Nc1nc(OC)ns1)N(C)c1ncnc2[nH]ccc12. References: Gu Y...
| Schlagworte: | ARQ252 |
| Anwendung: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1445987-21-2 |
| MW: | 414.48 D |
ab 69,00 €
