SGC-GAK-1

SGC-GAK-1 is an inhibitor of cyclin G-associated kinase (GAK, Ki = 3.1 nM). It is greater than 50-fold selective for GAK over a panel of 400 kinases at 1 µM but does bind to RIPK2 in a bioluminescence resonance energy transfer (BRET) engagement assay (IC50 = 360 nM). SCG-GAK-1 reduces the viability of LNCaP and 22Rv1 prostate cancer cells with IC50 values of 0.65 and 0.17 µM, respectively. It also inhibits dengue virus infection in Huh7 cells (EC50 = 0.08 µM).Formal Name: 6-bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine. CAS Number: 2226517-76-4. Molecular Formula: C18H17BrN2O3. Formula Weight: 389.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. lambdamax: 219, 252 nm. SMILES: BrC1=CC2=C(NC3=CC(OC)=C(C(OC)=C3)OC)C=CN=C2C=C1. InChi Code: InChI=1S/C18H17BrN2O3/c1-22-16-9-12(10-17(23-2)18(16)24-3)21-15-6-7-20-14-5-4-11(19)8-13(14)15/h4-10H,1-3H3,(H,20,21). InChi Key: AUOSKLDNVNGKRR-UHFFFAOYSA-N.