SGC-CBP30

cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and 38 nM, respectively). Developed by the Structural Genomics Consortium (SGC), this compound displays over 40-fold selectivity for CREBBP over BRD4(1) and is functional in cells.Formal Name: 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole. CAS Number: 1613695-14-9. Molecular Formula: C28H33ClN4O3. Formula Weight: 509.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 221, 287 nm. SMILES: COC(C=C1)=C(Cl)C=C1CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2C[C@H](C)N5CCOCC5. InChi Code: InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1. InChi Key: GEPYBHCJBORHCE-SFHVURJKSA-N.