SD 169

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38alpha (IC50 = 3.2 nM) and p38beta (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38gamma MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 µM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.Formal Name: 1H-indole-5-carboxamide. CAS Number: 1670-87-7. Synonyms: 5-Carbamoylindole. Molecular Formula: C9H8N2O. Formula Weight: 160.2. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 5 mg/ml, Ethanol: 1.4 mg/ml. lambdamax: 237, 276 nm. SMILES: NC(C1=CC=C(NC=C2)C2=C1)=O. InChi Code: InChI=1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12). InChi Key: GQMYQEAXTITUAE-UHFFFAOYSA-N.