SCR130

SCR130 is an inhibitor of non-homologous end joining (NHEJ) and a derivative of the DNA ligase IV inhibitor SCR7 (Cay-18015). It selectively inhibits DNA ligase IV- over ligase I- or ligase III-mediated end-joining in cell-free assays when used at a concentration of 200 µM. SCR130 is cytotoxic to NALM6 and Reh leukemia and HeLa cervical cancer cells (IC50s = 2.2, 14.1, and 5.9 µM, respectively) and induces DNA double-strand breaks (DSBs) in Reh cells when used at concentrations ranging from 7 to 21 µM.Formal Name: 2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4.5]dec-1-ene-6,10-dione. CAS Number: 2377858-38-1. Molecular Formula: C19H13Cl2N3O2S. Formula Weight: 418.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble (warmed, sonicated). lambdamax: 249, 292 nm. SMILES: O=C1NC(NC(C12N=C(CC2C3=CC=C(C=C3)Cl)C4=CC=C(Cl)C=C4)=O)=S. InChi Code: InChI=1S/C19H13Cl2N3O2S/c20-12-5-1-10(2-6-12)14-9-15(11-3-7-13(21)8-4-11)24-19(14)16(25)22-18(27)23-17(19)26/h1-8,14H,9H2,(H2,22,23,25,26,27). InChi Key: QEMQLCCYJLGAKB-UHFFFAOYSA-N.