Zu "K10777" wurden 35 Artikel gefunden!
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Anti-LIG4 / DNA Ligase 4
Artikelnummer: NSJ-FY13129
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. LIG4 antibody detects DNA ligase 4, an essential enzyme that catalyzes the final ligation step in non-homologous end joining (NHEJ) DNA repair. The UniProt recommended name is DNA ligase 4 (LIG4). This enzyme joins DNA double-strand breaks...
| Schlagworte: | Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, LIG4 Antibody / DNA Ligase 4 |
| Anwendung: | WB, ICC, IF, FC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
790,00 €
SCR7
Artikelnummer: Cay18015-10
DNA ligase IV seals double-strand breaks during the process of nonhomologous end-joining in DNA repair. Inhibiting this function in cancer cells is one strategy to prevent deleterious cell growth. SCR7 is a small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with ligase...
| Schlagworte: | 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone |
| Anwendung: | DNA ligase IV inhibitor |
| CAS | 1533426-72-0 |
| MW: | 334.4 D |
ab 49,00 €
LIG4 BRCT domains (human, recombinant)
Artikelnummer: Cay14169-100
DNA Ligase 4 (LIG4) is a large protein belonging to the ATP-dependent DNA ligase family. LIG4 contains two BRCA1 C-terminal (BRCT) domains. BRCT domains are modular units of ~100 amino acids that fold independently and recognize linear phosphoserine or phosphothreonine regions to mediate protein-protein and...
| Schlagworte: | LIG4, DNA ligase 4, DNA ligase 4, DNA ligase IV, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4,... |
| Anwendung: | Binding assays |
| Exprimiert in: | E.coli |
| MW: | 57,6 kD |
712,00 €
Anti-LIG4
Artikelnummer: ARG55278.100
Protein function: Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and...
| Schlagworte: | Anti-LIG4, EC=6.5.1.1, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
707,00 €
L189
Artikelnummer: Cay18374-5
L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 µM, respectively). It blocks DNA binding (Ki = 5 µM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA,...
| Schlagworte: | 6-amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone |
| Anwendung: | DNA ligase I, III, IV inhibitor |
| CAS | 64232-83-3 |
| MW: | 246.3 D |
ab 128,00 €
Anti-LIG4
Artikelnummer: E-AB-18863.120
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex...
| Schlagworte: | Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, LIG4 Polyclonal Antibody |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
Anti-LIG4
Artikelnummer: E-AB-52776.120
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex...
| Schlagworte: | Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, LIG4 Polyclonal Antibody |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
Anti-LIG4
Artikelnummer: ATA-HPA001334.100
Protein function: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and...
| Schlagworte: | Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-LIG4
Artikelnummer: ATA-HPA057325.100
Protein function: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and...
| Schlagworte: | Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4 |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
SCR130
Artikelnummer: Cay37779-1
SCR130 is an inhibitor of non-homologous end joining (NHEJ) and a derivative of the DNA ligase IV inhibitor SCR7 (Cay-18015). It selectively inhibits DNA ligase IV- over ligase I- or ligase III-mediated end-joining in cell-free assays when used at a concentration of 200 µM. SCR130 is cytotoxic to NALM6 and Reh...
| Schlagworte: | 2,4-bis(4-chlorophenyl)-8-thioxo-1,7,9-triazaspiro[4.5]dec-1-ene-6,10-dione |
| Anwendung: | NHEJ (non-homologous end joining) inhibitor |
| CAS | 2377858-38-1 |
| MW: | 418.3 D |
ab 40,00 €
Anti-LIG4
Artikelnummer: CSB-PA002168.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, DNA ligase IV ATP... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 126,00 €
Anti-LIG4
Artikelnummer: CSB-PA869550.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-LIG4, Anti-DNA ligase 4, Anti-DNA ligase IV, Anti-Polydeoxyribonucleotide synthase [ATP] 4, DNA ligase IV ATP... |
| Anwendung: | ELISA, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
284,00 €