Sabutoclax

Sabutoclax is a pan-inhibitor of the Bcl-2 family proteins Bcl-xL, Bcl-2, Mcl-1, and Bfl-1 (IC50s = 0.31, 0.32, 0.2, and 0.62 µM, respectively). It inhibits the proliferation of BP3 B cell lymphoma cells, as well as PC3 prostate and H460 lung cancer cells (IC50s = 0.049, 0.13, and 0.56 µM, respectively). Sabutoclax (5 mg/kg) reduces tumor growth in an M2182 prostate cancer mouse xenograft model.Formal Name: (1R)-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide. CAS Number: 1228108-65-3. Synonyms: BI-97C1. Molecular Formula: C42H40N2O8. Formula Weight: 700.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O=C(C1=C(C(O)=CC2=C1C=C(C)C(C3=C(C4=C(C=C3C)C(C(NCC(C)C5=CC=CC=C5)=O)=C(O)C(O)=C4)O)=C2O)O)NCC(C)C6=CC=CC=C6. InChi Code: InChI=1S/C42H40N2O8/c1-21-15-27-29(17-31(45)39(49)35(27)41(51)43-19-23(3)25-11-7-5-8-12-25)37(47)33(21)34-22(2)16-28-30(38(34)48)18-32(46)40(50)36(28)42(52)44-20-24(4)26-13-9-6-10-14-26/h5-18,23-24,45-50H,19-20H2,1-4H3,(H,43,51)(H,44,52). InChi Key: RAYNZUHYMMLQQA-UHFFFAOYSA-N.