Zu "K02161" wurden 305 Artikel gefunden!
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Human Bcl2 (B-Cell Leukemia/Lymphoma 2) ELISA Kit
Artikelnummer: ELK-ELK1524.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Bcl2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Bcl2. Next,...
| Schlagworte: | BCL2, Apoptosis regulator Bcl-2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Rat Bcl2 (B-Cell Leukemia/Lymphoma 2) ELISA Kit
Artikelnummer: ELK-ELK1525.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat Bcl2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat Bcl2. Next,...
| Schlagworte: | Bcl2, Bcl-2, Apoptosis regulator Bcl-2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Mouse Bcl2 (B-Cell Leukemia/Lymphoma 2) ELISA Kit
Artikelnummer: ELK-ELK1526.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Bcl2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Bcl2. Next,...
| Schlagworte: | Bcl2, Bcl-2, Apoptosis regulator Bcl-2 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
Venetoclax, Free Base (ABT-199, GDC-0199, CAS...
Artikelnummer: LC-V-3579_500mg
Soluble in DMSO
| Schlagworte: | GDC 0199,... |
| Anwendung: | BCL-2 inhibitor |
| CAS | 1257044-40-8 |
| MW: | 868,44 D |
ab 106,00 €
ABT-263
Artikelnummer: Cay11500-5
ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis = is = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50 value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment...
| Schlagworte: | A-855071, Navitoclax,... |
| Anwendung: | Potent, cell-permeable BH3 domain mimetic |
| CAS | 923564-51-6 |
| MW: | 974.6 D |
ab 33,00 €
ABT-199
Artikelnummer: Cay16233-25
B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death. The...
| Schlagworte: | Venetoclax, GDC 0199,... |
| Anwendung: | BCL-2 inhibitor |
| CAS | 1257044-40-8 |
| MW: | 868.4 D |
ab 72,00 €
ABT-199
Artikelnummer: LKT-A0776.5
ABT-199 is a BH3 mimetic that inhibits Bcl-2 but does not affect Bcl-xl. ABT-199 exhibits anticancer chemotherapeutic activity, inducing Bim-mediated apoptosis in chronic lymphocytic leukemia (CLL) cells. ABT-199 also induces cell death and inhibits tumor growth in acute myelogenous leukemia (AML) models in vitro,...
| Schlagworte: | GDC-0199 |
| Anwendung: | BH3 mimetic, Bcl-2 inhibitor |
| CAS | 1257044-40-8 |
| MW: | 868.44 D |
ab 69,00 €
ABT-737
Artikelnummer: Cay11501-25
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with...
| Schlagworte: | 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]am... |
| Anwendung: | Potent, cell-permeable BH3 domain mimetic |
| CAS | 852808-04-9 |
| MW: | 813.4 D |
ab 38,00 €
Obatoclax (mesylate)
Artikelnummer: Cay11499-1
Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and...
| Schlagworte: | GX15-070, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate |
| Anwendung: | Antagonist of Bcl-2 family members containing four Bcl-2 homology domains |
| CAS | 803712-79-0 |
| MW: | 413.5 D |
ab 84,00 €
ABT-737
Artikelnummer: SYN-1001-M005
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate...
| Schlagworte: | ABT737 |
| Anwendung: | Bcl-2 / Bcl-X(L) / Bcl-w inhibitor |
| CAS | 852808-04-9 |
| MW: | 813,4 D |
ab 79,00 €
TW-37
Artikelnummer: Cay20999-5
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of...
| Schlagworte: | N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-benzamide |
| Anwendung: | Bcl-2 / Mcl-1 / Bcl-xL inhibitor |
| CAS | 877877-35-5 |
| MW: | 573.7 D |
ab 147,00 €
Thymoquinone
Artikelnummer: Cay15039-1
The black seeds of Nigella have long been ingested to treat a broad range of diseases, including inflammation and cancer. Thymoquinone is a natural phytochemical isolated from the seeds of N. sativa. It has anti-inflammatory effects, blocking the synthesis of leukotrienes. Thymoquinone inhibits the growth of...
| Schlagworte: | NSC 2228, 2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione |
| Anwendung: | Apoptosis inducer |
| CAS | 490-91-5 |
| MW: | 164.2 D |
ab 43,00 €