S-(-)-Sulpiride

Sulpiride is an antipsychotic that functions as an antagonist at D2/3 receptors and also upregulates and activates the GHB receptor. In vivo, sulpiride ameliorates increased impulsivity and attentional impairment in PFC-lesioned models of schizophrenia. Additionally, because dopamine inhibits prolactin release, sulpiride's inhibition of dopamine results in increased concentrations of prolactin as well as melanocyte-stimulating hormone.