Rucaparib (phosphate)

Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is used as a therapeutic strategy to selectively target cancers. Rucaparib is a potent, cell-permeable inhibitor of PARP1 (Ki = 50 values ranging from 1.3-5.5 µM. At 25 mg/kg, rucaparib arrests tumor growth in mice bearing epigenetically silenced BRCA1 UACC3199 xenograft tumors. It has been shown to increase efficacy of temozolomide in medulloblastoma cells and xenografts. Rucaparib (phosphate) is the phosphate salt of rucaparib (Cay-15643) and has improved aqueous solubility.Formal Name: 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one, phosphate. CAS Number: 459868-92-9. Synonyms: AG-014699, PF-01367338. Molecular Formula: C19H18FN3O . H3PO4. Formula Weight: 421.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.5 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 208, 238, 279, 356 nm. SMILES: O=C1NCCC2=C(C3=CC=C(CNC)C=C3)NC4=CC(F)=CC1=C24.OP(O)(O)=O. InChi Code: InChI=1S/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15,1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24),(H3,1,2,3,4). InChi Key: FCCGJTKEKXUBFZ-UHFFFAOYSA-N.