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Rucaparib (phosphate)
Artikelnummer: Cay11570-1
Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is...
| Schlagworte: | AG-014699, PF-01367338,... |
| Anwendung: | PARP-1 inhibitor |
| CAS | 459868-92-9 |
| MW: | 421.4 D |
ab 49,00 €
Rucaparib Phosphate
Artikelnummer: TGM-T6127-100mg
Description: Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy. Target: PARP. Smiles: OP(O)(O)=O.CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23. References: Thomas HD, et al. Preclinical selection of a...
| Schlagworte: | AG-014699 phosphate, PF-01367338, AG-014699, PF-01367338 phosphate |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 459868-92-9 |
| MW: | 421.36 D |
ab 31,00 €
