Zu "K10798" wurden 193 Artikel gefunden!
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Olaparib
Artikelnummer: Cay10621-5
Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...
| Schlagworte: | AZD 2281, Ku-0059436, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone |
| Anwendung: | PARP1 / PARP2 inhibitor |
| CAS | 763113-22-0 |
| MW: | 434.5 D |
ab 70,00 €
Anti-PARP4
Artikelnummer: ABS-KC-43457.100
Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): 64%. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 64%, Pig - 74%, Cynomolgus monkey - 83%. IHC Verification: succeed. WB Verification: -. IP Verification: -. IF...
| Schlagworte: | Anti-PARP4, Anti-193 kDa vault protein, Anti-Poly [ADP-ribose] polymerase 4, Anti-Vault poly(ADP-ribose) polymerase,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Anti-PARP4
Artikelnummer: ABS-KC-43436.100
Formulation: Phosphate-buffered saline (PBS) with 50% glycerol, 0.5% BSA and 0.09% sodium azide. Identity-Mouse (%): 64%. Homologies: Highest antigen sequence identity to the following orthologs: Mouse - 64%, Pig - 74%, Cynomolgus monkey - 83%. IHC Verification: succeed. WB Verification: -. IP Verification: -. IF...
| Schlagworte: | Anti-PARP4, Anti-193 kDa vault protein, Anti-Poly [ADP-ribose] polymerase 4, Anti-Vault poly(ADP-ribose) polymerase,... |
| Anwendung: | IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 232,00 €
Anti-Human PARP4 Antibody Pair
Artikelnummer: ABS-ES-3976.1
Product Description: Poly(ADP-ribose) polymerase family member 4 (PARP4), also known as vault PARP (VPARP), is a large nuclear enzyme with structural and functional similarities to PARP1, including a BRCT domain, WGR domain, helical domain (HD), and ADP-ribosyltransferase (ART) domain, which together suggest a role...
| Schlagworte: | Anti-PARP4, Anti-193 kDa vault protein, Anti-Poly [ADP-ribose] polymerase 4, Anti-Vault poly(ADP-ribose) polymerase,... |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
Anti-Human PARP4 Antibody Pair
Artikelnummer: ABS-ES-3974.1
Product Description: Poly(ADP-ribose) polymerase family member 4 (PARP4), also known as vault PARP (VPARP), is a large nuclear enzyme with structural and functional similarities to PARP1, including a BRCT domain, WGR domain, helical domain (HD), and ADP-ribosyltransferase (ART) domain, which together suggest a role...
| Schlagworte: | Anti-PARP4, Anti-193 kDa vault protein, Anti-Poly [ADP-ribose] polymerase 4, Anti-Vault poly(ADP-ribose) polymerase,... |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
Anti-Human PARP4 Antibody Pair
Artikelnummer: ABS-ES-3975.1
Product Description: Poly(ADP-ribose) polymerase family member 4 (PARP4), also known as vault PARP (VPARP), is a large nuclear enzyme with structural and functional similarities to PARP1, including a BRCT domain, WGR domain, helical domain (HD), and ADP-ribosyltransferase (ART) domain, which together suggest a role...
| Schlagworte: | Anti-PARP4, Anti-193 kDa vault protein, Anti-Poly [ADP-ribose] polymerase 4, Anti-Vault poly(ADP-ribose) polymerase,... |
| Anwendung: | ELISA |
| Wirt: | Mouse/Mouse |
| Spezies-Reaktivität: | human |
1.080,00 €
PARP2, active human recombinant protein
Artikelnummer: BPS-80502
Active human PARP2 (GenBank Accession No. NM_005484), amino-acids 2-583 with N-terminal GST tag, MW = 92 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | ARTD2, PARP-2, ADPRT2, ADPRT-2, hPARP-2, pADPRT-2, Poly[ADP-ribose] synthase 2, Poly [ADP-ribose] polymerase 2, NAD(+)... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 92 kD |
879,00 €
BMN 673
Artikelnummer: Cay19782-1
BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM. It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG. BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits...
| Schlagworte: | Talazoparib,... |
| Anwendung: | Antineoplastic, PARP inhibitor |
| CAS | 1207456-01-6 |
| MW: | 380.4 D |
ab 112,00 €
Nicotinamide
Artikelnummer: LKT-N3310.50
A naturally occurring vitamin and a protease inhibitor. Topical nicotinamide has demonstrable preventive activity against photo carcinogenesis in mice by elevating skin nicotinamide-adenine dinucleotide (NAD) content. It also has protective effects against lung and pancreatic carcinogenesis. Niacinamide also...
| Schlagworte: | Niacinamide, nicotinic acid amide |
| Anwendung: | Protease inhibitor |
| CAS | 98-92-0 |
| MW: | 122,12 D |
ab 90,00 €
ABT-888 (hydrochloride)
Artikelnummer: Cay11505-5
Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis. ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively). It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including...
| Schlagworte: | Veliparib, 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride |
| Anwendung: | PARP1 / PARP2 inhibitor |
| CAS | 912445-05-7 |
| MW: | 317.2 D |
ab 69,00 €
DPQ
Artikelnummer: Cay14450-1
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can...
| Schlagworte: | PARP Inhibitor III, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone |
| Anwendung: | PARP inhibitor |
| CAS | 129075-73-6 |
| MW: | 302.4 D |
ab 87,00 €
PARP3, active human recombinant protein
Artikelnummer: BPS-80503
Active human PARP3 (GenBank Accession No. NM_001003931), full length with N-terminal GST tag, MW = 87 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | IRT1, ARTD3, PARP-3, ADPRT-3, hPARP-3, pADPRT-3, Poly[ADP-ribose] synthase 3, Poly [ADP-ribose] polymerase 3, NAD(+)... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 87 kD |
737,00 €