(-)-Rolipram

(-)-Rolipram is a phosphodiesterase 4 (PDE4) inhibitor (IC50 = 0.22 µM for the guinea pig eosinophil enzyme) and an enantiomer of (±)-rolipram (Cay-10011132). It enhances isoprenaline-induced cAMP accumulation in isolated guinea pig eosinophils (EC50 = 0.19 µM). (-)-Rolipram (1-1,000 µM) inhibits TNF and INF-gamma production in L1402 CD4+ encephalitogenic rat T cells. It inhibits ovalbumin-induced contraction of tracheal rings isolated from ovalbumin-sensitized guinea pigs when used at a concentration of 1 µM. (-)-Rolipram inhibits ovalbumin-induced bronchoconstriction in guinea pigs (ED50 = 0.25 mg/kg).Formal Name: (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone. CAS Number: 85416-75-7. Synonyms: (R)-(-)-Rolipram, (R)-Rolipram. Molecular Formula: C16H21NO3. Formula Weight: 275.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. SMILES: COC1=CC=C([C@@]2([H])CC(NC2)=O)C=C1OC3CCCC3. InChi Code: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1. InChi Key: HJORMJIFDVBMOB-LBPRGKRZSA-N.