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Zu "K13293" wurden 156 Artikel gefunden!
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Artikelnummer: Cay34075-1
BPN14770 is an inhibitor of phosphodiesterase 4D (PDE4D). It selectively inhibits dimeric PDE4DS129D and PDE4DS54D, which mimic the phosphorylated, activated forms of PDE4D, over wild-type dimeric PDE4D, dimeric PDE4DS133D, and monomeric PDE4D2 (IC50s = 7.8, 7.4, 1,018, 2,013, and 127 nM, respectively). BPN14770...
Schlagworte: | Zatolmilast, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-benzeneacetic acid |
Anwendung: | PDE4D inhibitor |
CAS | 1606974-33-7 |
MW: | 405.8 D |
ab 88,00 €
Artikelnummer: Cay39664-1
Difamilast is an inhibitor of phosphodiesterase 4 (PDE4). It is selective for the PDE4 isoforms PDE4A, PDE4B, PDE4C, and PDE4D (IC50s = 0.0832, 0.0112, 0.2493 and 0.0738 µM, respectively) over PDE5A and PDE10A (IC50s = 4.793 and 1.4346 µM, respectively) and eight other PDEs (IC50s = >10 µM for all). Difamilast...
Schlagworte: | OPA 15406, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-benzamide |
Anwendung: | PDE4 inhibitor |
CAS | 937782-05-3 |
MW: | 446.4 D |
ab 101,00 €
Artikelnummer: ELK-ELK7317.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PDE4B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PDE4B. Next,...
Schlagworte: | DPDE4, cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Anwendung: | ELISA |
Spezies-Reaktivität: | rat |
ab 365,00 €
Artikelnummer: ELK-ELK0900.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDE4B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDE4B. Next,...
Schlagworte: | PDE32, DPDE4, cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK0901.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDE4C. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDE4C. Next,...
Schlagworte: | PDE21, DPDE1, cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK0902.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDE4A. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDE4A. Next,...
Schlagworte: | PDE46, PDE4A, DPDE2, cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK3945.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PDE4D. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PDE4D. Next,...
Schlagworte: | DPDE3, PDE43, cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay10011132-5
Type 4 cyclic nucleotide phosphodiesterases (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. (±)-Rolipram is a cell-permeable selective PDE4 inhibitor. Since PDE4 is abundant in leukocytes, (±)-rolipram inhibits inflammation by suppressing...
Schlagworte: | SB 95952, ZK 62711, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
Anwendung: | PDE4 inhibitor |
CAS | 61413-54-5 |
MW: | 275.3 D |
ab 39,00 €
Artikelnummer: Cay14408-250
Bucladesine is a cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cyclic adenosine monophosphate (cAMP) and is a phosphodiesterase inhibitor. Because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions, bucladesine is widely...
Schlagworte: | DC 2797, N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate) 2'-butanoate-adenosine, monosodium salt |
Anwendung: | Cell-permeable cAMP mimic |
CAS | 16980-89-5 |
MW: | 491.4 D |
ab 48,00 €
Artikelnummer: Cay38778-10
D159687 is a negative allosteric modulator of phosphodiesterase 4D (PDE4D, IC50 = 28 nM for the human enzyme). It is selective for PDE4D over PDE4B (IC50 = 562 nM for the human enzyme), as well as 14 other PDE isoforms (IC50s = >1.4 µM). D159687 decreases forskolin-induced cAMP hydrolysis in HEK293 cells (IC50 = 253...
Schlagworte: | N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-urea |
Anwendung: | Negative allosteric PDE4D modulator |
CAS | 1155877-97-6 |
MW: | 366.8 D |
ab 88,00 €
Artikelnummer: Cay18502-5
Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP. It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis. Apremilast reduces both TNF-alpha and matrix...
Schlagworte: | CC-10004, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-acetamide |
Anwendung: | PDE4 inhibitor |
CAS | 608141-41-9 |
MW: | 460.5 D |
ab 84,00 €
Artikelnummer: Cay37793-10
RS 25344 is an inhibitor of phosphodiesterase 4 (PDE4, IC50 = 0.3 nM). It is selective for PDE4 over PDE1, -2, and -3 (IC50s = >100 µM for all). RS 25344 inhibits concanavalin A-induced IL-5 release and LPS-induced TNF-alpha release in isolated human peripheral blood mononuclear cells (PBMCs, EC50s = 0.3 and 5.4 nM,...
Schlagworte: | 1-(3-nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione |
Anwendung: | PDE4 inhibitor |
CAS | 152815-28-6 |
MW: | 411.8 D |
ab 48,00 €