Zu "K13293" wurden 209 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Nerandomilast
Artikelnummer: Cay44975-10
Nerandomilast is an inhibitor of phosphodiesterase 4B (PDE4B. IC50 = 0. µM). It is selective for PDE4B over PDE4A, PDE4C, and PDE4D (IC50s = 0. 8. and 0. µM, respectively), PDE7A, PDE3A, PDE1C, and PDE9A (IC50s = 14, 120, 46, and >100 µM, respectively), and does not inhibit PDE2A, PDE5, or PDE6. Nerandomilast...
| Schlagworte: | BI-1015550,... |
| Anwendung: | PDE4B inhibitor |
| CAS | 1423719-30-5 |
| MW: | 448.97 D |
ab 91,00 €
Anti-PDE4B / Phosphodiesterase 4B
Artikelnummer: NSJ-FY12523
Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PDE4B antibody detects Phosphodiesterase 4B, an enzyme that hydrolyzes cyclic AMP (cAMP) into AMP, terminating cAMP-dependent signaling. PDE4B belongs to the type 4 phosphodiesterase family, which provides fine control of intracellular cAMP...
| Schlagworte: | Anti-DPDE4, Anti-PDE4B, Anti-PDE32, Anti-cAMP-specific phosphodiesterase 4B, Anti-3',5'-cyclic-AMP phosphodiesterase 4B,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
790,00 €
(±)-Rolipram
Artikelnummer: Cay10011132-5
Type 4 cyclic nucleotide phosphodiesterases (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. (±)-Rolipram is a cell-permeable selective PDE4 inhibitor. Since PDE4 is abundant in leukocytes, (±)-rolipram inhibits inflammation by suppressing...
| Schlagworte: | SB 95952, ZK 62711, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
| Anwendung: | PDE4 inhibitor |
| CAS | 61413-54-5 |
| MW: | 275.3 D |
ab 44,00 €
Bucladesine (sodium salt)
Artikelnummer: Cay14408-250
Bucladesine is a cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cyclic adenosine monophosphate (cAMP) and is a phosphodiesterase inhibitor. Because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions, bucladesine is widely...
| Schlagworte: | DC 2797, N-(1-oxobutyl)-cyclic 3',5'-(hydrogen phosphate) 2'-butanoate-adenosine, monosodium salt |
| Anwendung: | Cell-permeable cAMP mimic |
| CAS | 16980-89-5 |
| MW: | 491.4 D |
ab 68,00 €
Ro 20-1724
Artikelnummer: Cay18272-50
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 µM). It weakly inhibits PDE3 with a Ki value greater than 25 µM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often...
| Schlagworte: | 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone, 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone |
| Anwendung: | Cell-permeable PDE4 inhibitor |
| CAS | 29925-17-5 |
| MW: | 278.4 D |
ab 49,00 €
Apremilast
Artikelnummer: Cay18502-5
Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP. It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis. Apremilast reduces both TNF-alpha and matrix...
| Schlagworte: | CC-10004, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-acetamide |
| Anwendung: | PDE4 inhibitor |
| CAS | 608141-41-9 |
| MW: | 460.5 D |
ab 97,00 €
PDE4A assay kit
Artikelnummer: BPS-60340
The PDE4A Assay Kit is designed for identification of PDE4A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE4A to the binding agent. PDE4A is widely expressed in brain tumors and promotes their growth and its inhibitor Rolipram...
| Schlagworte: | inhibitor screening, assay kit, PDE4A, |
| Anwendung: | PDE4A assays, inhibitor screening, FP |
804,00 €
PDE4D3, active human recombinant protein
Artikelnummer: BPS-60046
Active human PDE4D3 (GenBank Accession No. U50159), full length, with N-terminal GST tag, MW=102.4 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PDE43, DPDE3, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 102.4 kD |
745,00 €
PDE4A Isoform 4, GST-Tag, His-Tag Recombinant
Artikelnummer: BPS-60040
Active human PDE4A1A (GenBank Accession No. U97584), full length with N-terminal GST tag, MW= 100 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | PDE4A, PDE46, DPDE2, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 100 kD |
730,00 €
PDE4B1, active human recombinant protein
Artikelnummer: BPS-60041
Active human PDE4B1 (GenBank Accession No. NM_001037341), full length with N-terminal GST tag, MW= 109 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | DPDE4, PDE32, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 109 kD |
708,00 €
Drotaverine (hydrochloride)
Artikelnummer: Cay20944-10
Drotaverine is an alkaloid that has been described as an inhibitor of phosphodiesterase 4 and negative allosteric modulator of L-type Ca2+ channels.Formal Name: 1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinoline, monohydrochloride. CAS Number: 985-12-6. Molecular Formula: C24H31NO4 . HCl....
| Schlagworte: | 1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinoline, monohydrochloride |
| Anwendung: | PDE4 inhibitor |
| CAS | 985-12-6 |
| MW: | 434 D |
ab 103,00 €
Apremilast (CC-10004)
Artikelnummer: BPS-27735-1
Apremilast, also known as CC-10004, is a novel and potent small-molecule inhibitor of phosphodiesterase 4 (PDE4), a key enzyme involved in cyclic adenosine monophosphate (cAMP) degradation and cytokine production of inflammatory cells.
| Schlagworte: | Apremilast, CC-10004, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide, |
| Anwendung: | PDE4 inhibitor |
| MW: | 460.5 D |
ab 560,00 €