(±)-Rolipram

Type 4 cyclic nucleotide phosphodiesterases (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. (±)-Rolipram is a cell-permeable selective PDE4 inhibitor. Since PDE4 is abundant in leukocytes, (±)-rolipram inhibits inflammation by suppressing leukocyte function, inhibiting C5a-stimulated LTC4 synthesis in eosinophils (IC50 = 200 nM), and lipopolysaccharide-induced TNF synthesis in monocytes (IC50 = 360 nM). (±)-Rolipram also enhances neuronal survival, has antipsychotic effects in mice, and suppresses bone loss in ovariectomized rats.Formal Name: 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone. CAS Number: 61413-54-5. Synonyms: SB 95952, ZK 62711. Molecular Formula: C16H21NO3. Formula Weight: 275.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 231, 280 nm. SMILES: COC(C=CC(C1CC(NC1)=O)=C2)=C2OC3CCCC3. InChi Code: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18). InChi Key: HJORMJIFDVBMOB-UHFFFAOYSA-N.