Ricobendazole

Ricobendazole, also known as albendazole sulfate, is a benzimidazole agent that inhibits tubulin polymerization and is commonly used as an anthelmintic and antiparasitic agent, with IC90 values ranging from 3.8 x 10-2 to -4 µg/ml against Encephalitozoon species. In vitro, ricobendazole effectively kills Taenia cysts, with EC50 and EC99 values of 0.068 and 0.556 µg/ml, respectively, in 11-day cultures, and inhibits adherence in Giardia species with a 24-hour IC50 value of 3.15 µM. This agent is metabolized from albendazole via cytochrome P450 (CYP450) and may modulate CYP450 activity. In rat microsomes, ricobendazole reduces the activity of ethoxyresorufin O-deethylase (EROD) by more than 5-fold relative to albendazole, with an IC50 value of 5 µM.Formal Name: N-[6-(propylsulfinyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester. CAS Number: 54029-12-8. Synonyms: Albendazole sulfoxide. Molecular Formula: C12H15N3O3S. Formula Weight: 281.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. lambdamax: 224, 294 nm. SMILES: O=C(OC)NC1=NC2=CC=C(S(CCC)=O)C=C2N1. InChi Code: InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16). InChi Key: VXTGHWHFYNYFFV-UHFFFAOYSA-N.