RHPS4 (methyl sulfate)

RHPS4 is a telomerase inhibitor (IC50 = 0.33 µM). It is a ligand for the guanine quadruplex (G-quadruplex), a four-stranded DNA secondary structure formed from G-rich DNA sequences, that intercalates and stabilizes the G-quadruplex, which inhibits the activity of telomerase. RHPS4 (1 µM) induces phosphorylation of H2AX on telomeres, indicating telomeric DNA damage, in BJ fibroblasts expressing human telomerase. It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 13.18 µM), as well as induces cell cycle arrest at the S-G2/M and apoptosis in M14 melanoma cells when used at concentrations ranging from 0.5 to 10 µM. RHPS4 (10 mg/kg) reduces tumor growth in several mouse xenograft models, including melanoma, lung, breast, and colon cancer models.Formal Name: 3,11-difluorohydro-6,8,13-trimethyl-quino[4,3,2-kl]acridinium, methyl sulfate. CAS Number: 390362-78-4. Molecular Formula: C22H17F2N2 . CH3SO4. Formula Weight: 458.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 237, 294 nm. SMILES: FC1=CC=C(N(C)C2=CC(C)=CC3=C(C=C(F)C=C4)C4=[N+](C)C5=C23)C5=C1.O=S(OC)([O-])=O. InChi Code: InChI=1S/C22H17F2N2.CH4O4S/c1-12-8-16-15-10-13(23)4-6-18(15)26(3)22-17-11-14(24)5-7-19(17)25(2)20(9-12)21(16)22,1-5-6(2,3)4/h4-11H,1-3H3,1H3,(H,2,3,4)/q+1,/p-1. InChi Key: VRWGYMXWYZBBGF-UHFFFAOYSA-M.