Zu "K11126" wurden 95 Artikel gefunden!
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Anti-TERT
Artikelnummer: NSJ-F54238-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for...
| Schlagworte: | Anti-TERT, Anti-HEST2, Anti-Telomerase catalytic subunit, Anti-Telomerase-associated protein 2, Anti-Telomerase reverse... |
| Anwendung: | WB, IHC (paraffin), FC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 361,00 €
Anti-Telomerase (hTERT Catalytic Unit)
Artikelnummer: 600-401-252
Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the...
| Schlagworte: | Anti-TP2, Anti-TERT, Anti-EST2, Anti-HEST2, EC=2.7.7.49, Anti-Telomerase catalytic subunit, Anti-Telomerase-associated... |
| Anwendung: | ELISA, IHC, IFM, IP, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 180,00 €
Cycloastragenol
Artikelnummer: Cay11722-100
Cycloastragenol, the aglycone derivative of astragaloside A (Cay-16677), can be found in various species of Astragalus and is reported to activate telomerase. It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients.Formal...
| Schlagworte: | Astramembrangenin, Cyclogalegigenin, 20,24R-epoxy-9,19-cyclolanostane-3beta,6alpha,16beta,25-tetrol |
| Anwendung: | Reported telomerase activator |
| CAS | 84605-18-5 |
| MW: | 490.7 D |
ab 38,00 €
360A (iodide)
Artikelnummer: Cay42501-10
360A is an inhibitor of telomerase (IC50 = 0. µM). It decreases the viability of in T98G glioma fibroblasts, CB193 astrocytoma and U-118 MG glioma cells, and primary human astrocytes (IC50s = 4. 3. 8. and 17. µM, respectively). 360A (5 µM) induces sister chromatid fusions and telomere loss in HeLa cervical cancer...
| Schlagworte: | 3,3'-[2,6-pyridinediylbis(carbonylimino)]bis[1-methyl-quinolinium, diiodide |
| Anwendung: | Telomerase inhibitor |
| CAS | 737763-37-0 |
| MW: | 703.3 D |
ab 281,00 €
BIBR 1532
Artikelnummer: Cay16608-10
BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on...
| Schlagworte: | Telomerase Inhibitor X, 2-[[(2E)-3-(2-naphthalenyl)-1-oxo-2-buten-1-yl]amino]-benzoic acid |
| Anwendung: | Telomerase / TERT inhibitor |
| CAS | 321674-73-1 |
| MW: | 331.4 D |
ab 49,00 €
TMPyP4 (tosylate)
Artikelnummer: Cay18474-50
TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues. In this way, TMPyP4 inhibits telomerase activity (IC50 = 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo....
| Schlagworte: | TMP-1363, TMPyP4 4-methylbenzenesulfonate,... |
| Anwendung: | G-quadruplex stabilizer, telomerase inhibitor |
| CAS | 36951-72-1 |
| MW: | 1363.6 D |
ab 56,00 €
Gossypol-acetic acid
Artikelnummer: LKT-G5875.1
A potential male anti-fertility agent from cotton that exhibits a wide spectrum of toxicity. It was found to have cytotoxic effects on human cancer cell lines. It is a potent telomerase inhibitor.
| Schlagworte: | 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1- methylethyl)(2,2'-binaphthalene)-8,8'-dicarboxaldehyde-acetic acid,... |
| Anwendung: | Telomerase inhibitor |
| CAS | 12542-36-8 |
| MW: | 578,61 D |
ab 152,00 €
beta-Rubromycin
Artikelnummer: BVT-0251-M001
Antibiotic, HIV-1 reverse transcriptase inhibitor, Human telomerase inhibitor, Cytostatic against different tumor cell lines. Isolated from Streptomyces sp.
| Schlagworte: | Methyl-8,10'-dihydroxy-5,7-dimethoxy-4,9,9'-trioxo-4,4',9,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g... |
| Anwendung: | Human telomerase inhibitor, HIV-1 reverse transcriptase inhibitor |
| CAS | 27267-70-5 |
| MW: | 536,4 D |
ab 85,00 €
gamma-Rubromycin
Artikelnummer: BVT-0007-M001
Antibiotic, HIV-1 reverse transcriptase and human telomerase inhibitor, Antibacterial, Cytostatically active against different tumor cell lines. Isolated from Streptomyces sp.
| Anwendung: | Human telomerase inhibitor |
| CAS | 27267-71-6 |
| MW: | 522,4 D |
ab 90,00 €
Costunolide
Artikelnummer: Cay14743-1
Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 µM) and induces apoptosis in assorted cancer cell lines. Costunolide inhibits the activation of Akt (15 µM) in endometriotic epithelial cells and STAT3 activation...
| Schlagworte: | Costus lactone, Melampolide, NSC 106404, 3aS,4,5,8,9,11aR-hexahydro-6E,10E-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one |
| Anwendung: | Apoptosis inducer |
| CAS | 553-21-9 |
| MW: | 232.3 D |
ab 44,00 €
6-thio-2'-Deoxyguanosine
Artikelnummer: Cay19154-1
6-thio-2'-Deoxyguanosine (6-thio-dG) is a purine nucleoside analog. It reduces infection of Calu-3 cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, EC50 = 0.04 µM) but is also toxic to Calu-3 cells with a 50% cytotoxic concentration (CC50) value of 1.14 µM. 6-Thio-dG (2 mg/kg) decreases tumor...
| Schlagworte: | 6-thio-dG, NSC 71261, beta-Thioguanine deoxyriboside, 2'-deoxy-6-thio-guanosine |
| Anwendung: | Nucleoside analog, telomeric DNA damage inducer |
| CAS | 789-61-7 |
| MW: | 283.3 D |
ab 49,00 €
Anti-TERT
Artikelnummer: ARG65609.100
Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the...
| Schlagworte: | Anti-TP2, Anti-TERT, Anti-EST2, Anti-HEST2, EC=2.7.7.49, Anti-Telomerase catalytic subunit, Anti-Telomerase-associated... |
| Anwendung: | WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €