Reparixin

Reparixin is an allosteric antagonist of chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 (IC50s = 1 and 100 nM, respectively). In vivo, reparixin (3, 15, and 30 mg/kg) reduces ischemia and reperfusion-induced hepatic polymorphonuclear leukocyte (PMN) recruitment, hepatic myeloperoxidase (MPO) levels, and serum alanine transaminase (ALT) levels in a rat model of hepatic ischemia. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg. Reparixin, in combination with docetaxel (Cay-11637), reduces tumor volume and the number of intratumor cancer stem cells in a SUM159 triple-negative breast cancer (TNBC) mouse xenograft model.Formal Name: (alphaR)-alpha-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide. CAS Number: 266359-83-5. Synonyms: DF 1681Y, Repertaxin. Molecular Formula: C14H21NO3S. Formula Weight: 283.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 15 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 220 nm. SMILES: CC(C)CC1=CC=C([C@@H](C)C(NS(C)(=O)=O)=O)C=C1. InChi Code: InChI=1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)/t11-/m1/s1. InChi Key: KQDRVXQXKZXMHP-LLVKDONJSA-N.