(R,S)-3,5-DHPG

(R,S)-3,5-DHPG is an agonist of group I metabotropic glutamate receptors (mGluRs). It induces phosphoinositol hydrolysis in MCB3901, also known as AV12-664, cells expressing human mGluR1a and mGluR5a in a concentration-dependent manner. (R,S)-3,5-DHPG (10 µM) potentiates NMDA-induced depolarizations in rat hippocampal slices. Intrathecal administration of (R,S)-3,5-DHPG (300 nmol/animal) increases mean blood pressure in anesthetized rats. Intracerebroventricular administration of (R,S)-3,5-DHPG (1.5 µmol/animal) induces seizures in rats.Formal Name: alpha-amino-3,5-dihydroxy-benzeneacetic acid. CAS Number: 146255-66-5. Synonyms: DL-3,5-Dihydroxyphenylglycine, (R,S)-3,5-Dihydroxyphenylglycine. Molecular Formula: C8H9NO4. Formula Weight: 183.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml, Water: 1 mg/ml. SMILES: O=C(C(C1=CC(O)=CC(O)=C1)N)O. InChi Code: InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13). InChi Key: HOOWCUZPEFNHDT-UHFFFAOYSA-N.