Pranoprofen

Pranoprofen is a non-steroidal anti-inflammatory drug (NSAID) and COX-1 inhibitor (IC50 = 3.1 µM). It decreases B. pertussis-induced production of prostaglandin E2 (PGE2, Cay-14010) in isolated rat peritoneal leukocytes (IC50 = 0.39 µM). Ocular application of pranoprofen reduces corneal epithelial damage in a mouse model of corneal alkali burns.Formal Name: alpha-methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid. CAS Number: 52549-17-4. Synonyms: Pyranoprofen, Y 8004. Molecular Formula: C15H13NO3. Formula Weight: 255.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 247, 276 nm. SMILES: OC(C(C)C1=CC(CC2=CC=CN=C2O3)=C3C=C1)=O. InChi Code: InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18). InChi Key: TVQZAMVBTVNYLA-UHFFFAOYSA-N.