PKUMDL-LC-101-D04

PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4). It increases GPX4 activity to 150% of control levels when used at a concentration of 20 µM in a cell-free assay and at 61 µM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 µM) also reduces cholesterol hydroperoxide-induced MEF death.Formal Name: N-(2-aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide, monohydrochloride. CAS Number: 2143896-83-5. Molecular Formula: C14H22N4O2S2 . HCl. Formula Weight: 378.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 260, 291 nm. SMILES: S=C(NC1CCCC1)NC2=CC=C(S(NCCN)(=O)=O)C=C2.Cl. InChi Code: InChI=1S/C14H22N4O2S2.ClH/c15-9-10-16-22(19,20)13-7-5-12(6-8-13)18-14(21)17-11-3-1-2-4-11,/h5-8,11,16H,1-4,9-10,15H2,(H2,17,18,21),1H. InChi Key: FELDRJSFLBINQS-UHFFFAOYSA-N.