Zu "K05361" wurden 107 Artikel gefunden!
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(1S,3R)-RSL3
Artikelnummer: Cay19288-5
(1S,3R)-RSL3 is a ferroptosis inducer and is canonically known as an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits GPX4 in a context-dependent manner: (1S,3R)-RSL3 inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3epsilon, an adaptor protein, but does not inhibit recombinant human...
| Schlagworte: | (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,... |
| Anwendung: | GPX4 inhibitor |
| CAS | 1219810-16-8 |
| MW: | 440.9 D |
ab 55,00 €
Anti-GPX4 / Glutathione Peroxidase 4
Artikelnummer: NSJ-RQ8921
0.5mg/ml if reconstituted with 0.2ml sterile DI water. GPX4 Antibody targets Glutathione Peroxidase 4, a selenium-dependent antioxidant enzyme encoded by the GPX4 gene that plays a critical role in protecting cells from oxidative damage. Glutathione Peroxidase 4 belongs to the glutathione peroxidase family and is...
| Schlagworte: | Anti-GPX4, Anti-Glutathione peroxidase 4, Anti-Phospholipid hydroperoxide glutathione peroxidase GPX4, GPX4 Antibody /... |
| Anwendung: | WB, IHC (paraffin), IP, FC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat, monkey |
790,00 €
Liproxstatin-1
Artikelnummer: Cay17730-5
Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by...
| Schlagworte: | N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine |
| Anwendung: | Ferroptosis inhibitor |
| CAS | 950455-15-9 |
| MW: | 340.9 D |
ab 97,00 €
Anti-Recombinant GPX4, clone 11A8
Artikelnummer: E-AN300726L.100
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in...
| Schlagworte: | Anti-GPX4, Anti-Glutathione peroxidase 4, Anti-Phospholipid hydroperoxide glutathione peroxidase GPX4, Recombinant GPX4... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 257,00 €
Anti-Recombinant Glutathione Peroxidase 4, clone A587
Artikelnummer: E-AN301875L.100
The selenoprotein glutathione peroxidase 4 (GPX4) is a master regulator of ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation. GPX4 converts lipid hydroperoxides to non-toxic lipid alcohols, therefore preventing ferroptosis. Research studies show that selenium enhances GPX4...
| Schlagworte: | Anti-GPX4, Anti-Glutathione peroxidase 4, Anti-Phospholipid hydroperoxide glutathione peroxidase GPX4, Recombinant... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 303,00 €
DEL-I25
Artikelnummer: Cay44052-1
DEL-I25 is an activator of glutathione peroxidase 4 (GPX4) containing the loss-of-function mutation R152H (GPX4R152H). It selectively binds to GPX4R152H over wild-type GPX4 (Kds = 2 and 110 µM, respectively). DEL-I25 increases the viability of fibroblasts expressing GPX4R152H isolated from patients with...
| Schlagworte: | 5-amino-N-[1-[2-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)acetyl]-3-azetidinyl]-2-pyridinepropanamide |
| Anwendung: | GPX4-R152H activator |
| CAS | 3036889-54-7 |
| MW: | 393.45 D |
ab 49,00 €
Altretamine-d18
Artikelnummer: Cay9003471-1
Altretamine-d18 is intended for use as an internal standard for the quantification of altretamine (Cay-23662) by GC- or LC-MS. Altretamine is an anticancer agent. It induces cytotoxicity in an ovarian cancer cell line when used at a concentration of 10 µg/ml. Altretamine (0. mM) inhibits glutathione peroxidase 4...
| Schlagworte: | 2,4,6-Tris(dimethylamino)-1,3,5-triazine-d18, Hexamethylmelamine-d18, HMM-d18,... |
| Anwendung: | GC-MS, LC-MS internal standard, quantification, antineoplastic |
| CAS | 65886-69-3 |
| MW: | 228.4 D |
ab 114,00 €
GPX4 (R)-9i
Artikelnummer: Cay43737-1
GPX4 (R)-9i is a ferroptosis inducer. It binds to GPX4 in a cellular thermal shift assay (CETSA) using HT-1080 fibrosarcoma cells (Kd = 20. nM) and inhibits GPX4 activity in a cell-free assay. It is cytotoxic to HT-1080 cells, an effect that can be reversed by the ferroptosis inhibitor ferrostatin-1 (IC50s = 0. and...
| Schlagworte: | Glutathione Peroxidase 4 (R)-9i |
| Anwendung: | Ferroptosis inducer |
| MW: | 540.66 D |
ab 184,00 €
FIN56
Artikelnummer: Cay25180-5
FIN56 is an inducer of ferroptosis and a derivative of CIL56 (Cay-19287). It selectively induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein. This effect is reversed by the ferroptosis inhibitors deferoxamine (Cay-14595) and...
| Schlagworte: | N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide |
| Anwendung: | Ferroptosis inducer |
| CAS | 1083162-61-1 |
| MW: | 517.7 D |
ab 104,00 €
FINO2
Artikelnummer: Cay25096-1
FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis. It also oxidizes iron in vitro,...
| Schlagworte: | (5alpha,8alpha)-8-(1,1-dimethylethyl)-3-methyl-1,2-dioxaspiro[4.5]decane-3-ethanol |
| Anwendung: | Ferroptosis-inducing peroxide compound |
| CAS | 869298-31-7 |
| MW: | 256.4 D |
ab 116,00 €
GPX4 (human, recombinant, His-tagged)
Artikelnummer: Cay26906-50
Glutathione peroxidase 4 (GPX4) is a selenocysteine-containing glutathione peroxidase that is encoded by the GPX4 gene in humans and protects cellular membranes from oxidative damage. It is a monomeric protein consisting of a thioredoxin motif and a selenocysteine-glutamine-tryptophan catalytic triad that reduces...
| Schlagworte: | PHGPx, PHGPx, GPx-4 {ECO:0000303|PubMed:9705830}, GPx-4 {ECO:0000303|PubMed:9705830}, GSHPx-4... |
| Anwendung: | Enzyme assays |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 21.2 kD |
920,00 €
N6F11
Artikelnummer: Cay39919-25
N6F11 is an inducer of ferroptosis. It increases the thermal stability of the ubiquitin ligase TRIM25 in a cellular thermal shift assay (CETSA) using PANC-1 pancreatic cancer cells when used at a concentration of 10 µM and enhances TRIM25-dependent ubiquitination of glutathione peroxidase 4 (GPX4) in a cell-free...
| Schlagworte: | 2-(chloromethyl)-6-(4-chlorophenyl)-thieno[3,2-d]pyrimidin-4(3H)-one |
| Anwendung: | Ferroptosis inducer, GPX4 degradation inducer |
| CAS | 851398-76-0 |
| MW: | 313.2 D |
ab 55,00 €