Pimitespib

Description: Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90alpha/HSP90beta inhibitor with inhibition constants (Kis) of 34.7 nM and 21.3 nM, respectively. Target: HSP. Smiles: CCc1cc(ccc1-n1nc(C(C)C)c2c(ccnc12)-n1cnc(c1)-c1cnn(C)c1)C(N)=O. References: Ohkubo S, et al. TAS-116, a highly selective inhibitor of heat shock protein 90alpha and beta, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models. Mol Cancer Ther. 2015 Jan,14(1):14-22.