Phosphoramidon (sodium salt)

Neprilysin (NEP) and NEP2 are membrane-bound zinc metalloproteases. Phosphoramidon is a natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes. It is also a weak inhibitor of the related zinc metalloprotease endothelin-converting enzyme (Ki = 3.5 µM). Phosphoramidon has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin, and angiotensin-converting enzyme.Formal Name: N-[N-[[(6-deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan, disodium salt. CAS Number: 164204-38-0. Molecular Formula: C23H34N3O10P . 2Na. Formula Weight: 589.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 14 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 223, 283 nm. SMILES: O=C([C@H](CC(C)C)NP(O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)(O)=O)N[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3.[Na].[Na]. InChi Code: InChI=1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15,,/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34),,/t12-,16-,17-,18-,19+,20+,23-,,/m0.. InChi Key: FJGLTVKFHSZNQE-ODIUWQMJSA-N.